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Thyroid status, disability and cognitive function, and survival in old age.
- J. Gussekloo, E. van Exel, A. D. de Craen, A. Meinders, M. Frölich, R. Westendorp
- 1 December 2004
CONTEXT Despite the equivocal outcomes of randomized controlled trials, general clinical opinion favors screening and treatment of elderly individuals with subclinical thyroid disorders. OBJECTIVES… Expand
Systemic Markers of Inflammation and Cognitive Decline in Old Age
OBJECTIVES: To investigate whether higher circulating levels of C‐reactive protein (CRP), interleukin‐6 (IL‐6), and α1‐antichymotrypsin (ACT) are associated with worse cognitive function and decline… Expand
Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age
- A. V. D. Biggelaar, J. Gussekloo, A. Craen, M. Frölich, R. Westendorp
- Experimental Gerontology
- 1 July 2007
The association between inflammation and neuropsychiatric symptoms in old age is generally accepted but poorly understood. The purpose of this study was to examine whether inflammation precedes… Expand
Anti-inflammatory cytokine profile and mortality in febrile patients
- J. Dissel, P. V. Langevelde, R. Westendorp, K. Kwappenberg, M. Frölich
- The Lancet
- 28 March 1998
BACKGROUND An anti-inflammatory cytokine profile on whole-blood stimulation in vitro is associated with fatal outcome of meningococcal disease. We investigated whether an anti-inflammatory cytokine… Expand
Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study.
- E. van Exel, J. Gussekloo, A. D. de Craen, M. Frölich, A. Bootsma-van der Wiel, R. Westendorp
- Biology, Medicine
- 1 April 2002
It has been suggested that the metabolic syndrome and type 2 diabetes are manifestations of the inflammatory host response. This host response is orchestrated by the production of pro- and… Expand
Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study.
- S. Mooijaart, J. Gussekloo, +4 authors A. D. de Craen
- The American journal of clinical nutrition
- 1 October 2005
BACKGROUND High concentrations of homocysteine and low concentrations of vitamin B-12 and folic acid are frequently observed in subjects with dementia. OBJECTIVE We assessed whether serum… Expand
Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation.
BACKGROUND & AIMS Infection is the primary cause of death after liver transplantation. Mannose binding lectin (MBL) is a recognition molecule of the lectin pathway of complement and a key component… Expand
Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study
- R. Westendorp, D. van Heemst, +7 authors P. Slagboom
- Journal of the American Geriatrics Society
- 1 September 2009
OBJECTIVES: To compare the risk of mortality of nonagenarian siblings with that of sporadic nonagenarians (not selected on having a nonagenarian sibling) and to compare the prevalence of morbidity in… Expand
Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease
Sleep disturbances are very prevalent in Huntington’s disease (HD) patients and can substantially impair their quality of life. Accumulating evidence suggests considerable dysfunction of the… Expand
Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function
Objective: To test the hypothesis that a pro-inflammatory response is associated with cognitive impairment among individuals with cardiovascular disease. Method: All 85-year-old inhabitants of Leiden… Expand