Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology.
- B. Roques, F. Noble, V. Daugé, M. Fournié-Zaluski, A. Beaumont
- BiologyPharmacological Reviews
- 1 March 1993
Δ9‐tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect
- O. Valverde, F. Noble, F. Beslot, V. Daugé, M. Fournié-Zaluski, B. Roques
- BiologyEuropean Journal of Neuroscience
- 1 May 2001
Behavioural and biochemical results demonstrate the existence of a direct link between endogenous opioid and cannabinoid systems, however, chronic use of high doses of cannabinoids does not seem to potentiate the psychic dependence to opioids.
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
- O. Valverde, R. Maldonado, M. Fournié-Zaluski, B. Roques
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 July 1994
An opposing physiological role of endogenous CCK, acting on CCK B receptors, and opioid peptides in the control of pain perception at both spinal and supraspinal levels is demonstrated.
Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation.
- A. Baamonde, V. Daugé, B. Roques
- Biology, PsychologyEuropean Journal of Pharmacology
- 5 June 1992
Acute effect of the dual angiotensin‐converting enzyme and neutral endopeptidase 24‐11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat
- V. Arbin, N. Claperon, M. Fournié-Zaluski, B. Roques, J. Peyroux
- Biology, MedicineBritish Journal of Pharmacology
- 1 June 2001
Results show that in obese insulin‐resistant Zucker rats, under acute conditions, NEP or ACE inhibition can improve IMGD and that dual ACE/NEP inhibition improves IMGD more effectively than does either single inhibition.
"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes.
- M. Fournié-Zaluski, P. Coric, B. Roques
- Chemistry, BiologyJournal of Medicinal Chemistry
- 26 June 1992
The analgesic potencies of the "mixed inhibitor-prodrug" RB 101 were three times greater than those of a similar combined dose of its two constitutive moieties, and the separation of the two diastereoisomers constituting RB 101 showed that the analgesia has a stereochemical dependence.
Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation.
- C. Abbadie, P. Honore, M. Fournié-Zaluski, B. Roques, J. Besson
- BiologyEuropean Journal of Pharmacology
- 13 June 1994
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
- F. Noble, S. Turcaud, M. Fournié-Zaluski, B. Roques
- BiologyEuropean Journal of Pharmacology
- 13 November 1992
Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.
- M. Fournié-Zaluski, P. Coric, B. Roques
- Chemistry, BiologyJournal of Medicinal Chemistry
- 3 April 1992
The results show that the disulfide forms of beta-amino thiols are efficient prodrugs of aminopeptidase N inhibitors capable of crossing the blood-brain barrier.
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
- F. Noble, P. Coric, M. Fournié-Zaluski, B. Roques
- BiologyEuropean Journal of Pharmacology
- 13 November 1992
...
...