• Publications
  • Influence
A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids
TLDR
The cloning of TRAAK, a 398 amino acid protein which is a new member of this mammalian class of K+ channels, is reported, which can be stimulated by arachidonic acid and other unsaturated fatty acids but not by saturated fatty acids. Expand
Molecular Properties of Neuronal G-protein-activated Inwardly Rectifying K+ Channels (*)
TLDR
Since the nonhydrolyzable ATP analog AMP-PCP is also active and since addition of kinases A and C as well as alkaline phosphatase does not modify the ATP effect, it is concluded that ATP hydrolysis is not required. Expand
TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel*
TLDR
This report shows that TRAAK, which was known to be activated by arachidonic acid, is also opened by membrane stretch and may play an important role during growth cone motility and neurite elongation in the central nervous system. Expand
TWIK-2, an Inactivating 2P Domain K+ Channel*
TLDR
The base-line, transient, and delayed activities of TWIK-2 suggest that this novel 2P domain K+ channel may play an important functional role in cell electrogenesis. Expand
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.
TLDR
Three novel 2P domain K(+) channel subunits from human are isolated and a third subunit, named hTHIK-2, is cloned which is present in many tissues with high levels again in the pancreas but which could not be functionally expressed. Expand
The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.
TLDR
A 86Rb+ flux technique is described that permits one to study easily the properties of ATP-modulated K+ channels in RINm5F insulinoma cells and there was an excellent correlation between efficacy of blockade and efficacy of binding to the sulfonylurea receptors using the 3H-ligand. Expand
Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels.
TLDR
Sulfonylurea-sensitive adenosine triphosphate (ATP)-regulated potassium (KATP) channels are present in brain cells and play a role in neurosecretion at nerve terminals, and may be involved in the response of the brain to hyper- and hypoglycemia and ischemia or anoxia. Expand
Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices
TLDR
Electrophysiological studies with hippocampal slices show that glibenclamide blocks hyperpolarization induced by anoxia, suggesting the involvement of adenosine triphosphate-sensitive K+ channel in this early hyperpolarsization event. Expand
Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure*
TLDR
Mouse KCNK6 is a new subunit belonging to the TWIK channel family that displays an intriguing GLE sequence in its filter region instead of the G(Y/F/L)G sequence, which is considered to be the K+ channel signature. Expand
[3H]nitrendipine receptors in skeletal muscle.
TLDR
The richest source of receptors for the organic calcium channel blocker [3H]nitrendipine in muscle is the transverse tubule membrane and the binding is destroyed by proteases showing that the receptor is a protein. Expand
...
1
2
3
4
5
...