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An improved mouse model for endometriosis allows noninvasive assessment of lesion implantation and development.
OBJECTIVE To test whether fragments of human endometrium transduced with the green fluorescent protein (GFP) cDNA and transplanted into nude mice can be noninvasively visualized. DESIGN A murine… Expand
Apoptosis Mediated Through CD45 Is Independent of Its Phosphatase Activity and Association with Leukocyte Phosphatase-Associated Phosphoprotein1
- M. Fortin, Ann-Muriel Steff, +4 authors P. Hugo
- Medicine, Biology
- The Journal of Immunology
- 15 June 2002
Besides the well-recognized role of CD45 as a major player in TCR signaling, we and others have demonstrated that cross-linking of CD45 with mAbs can induce cell death in T lymphocytes. To… Expand
The osteoblastic phenotype in calcium-depleted and calcium-repleted rats: a structural and histomorphometric study.
- E. Bonucci, P. Mocetti, +4 authors A. Nanci
- Medicine, Materials Science
- Journal of electron microscopy
- 1 July 2001
In a previous report we showed that young rats fed a calcium-free diet for 28 days developed severe hypocalcaemia and showed a significant increase in serum alkaline phosphatase activity. The main… Expand
Detection of a decrease in green fluorescent protein fluorescence for the monitoring of cell death: an assay amenable to high-throughput screening technologies.
BACKGROUND Reliable assessment of cell death is now pivotal to many research programs aiming at generating new anti-tumor compounds or at screening cDNA libraries. Such approaches need to rely on… Expand
Quantitative assessment of human endometriotic tissue maintenance and regression in a noninvasive mouse model of endometriosis.
- M. Fortin, Manon Lépine, +5 authors Ann-Muriel Steff
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 1 April 2004
Endometriosis is a prevalent disease characterized by the estrogen-dependent ectopic growth of endometrial tissue. Most of the current medical therapies consist in inducing a hypoestrogenic state in… Expand
A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice
BackgroundRecent development in the field of COPD has focused on strategies aimed at reducing the underlying inflammation through selective inhibition of the phosphodiesterase type IV (PDE4) isoform.… Expand
TGF‐β2 and PGE2 in Rabbit Blastocoelic Fluid Can Modulate GM‐CSF Production by Human Lymphocytes
- M. Fortin, M. Ouellette, R. Lambert
- Biology, Medicine
- American journal of reproductive immunology
- 1 August 1997
PROBLEM: During normal pregnancy, major changes occur in the production of Th2/Th1 cytokines at the feto‐maternal interface. Th2 cytokines such as interleukin‐4 (IL‐4) or interleukin‐10 (IL‐10) are… Expand
Effects of antisense oligodeoxynucleotides targeting CCR3 on the airway response to antigen in rats.
Asthma is characterized by airway hyperresponsiveness (AHR) and inflammation, consisting predominantly of eosinophils within the airway lumen and walls. Eosinophil recruitment to the airways is… Expand
Surface antigen detection with non-fluorescent, antibody-coated microbeads: an alternative method compatible with conventional fluorochrome-based labeling.
BACKGROUND Our goal was to devise a new labeling technique allowing the flow cytometric detection of an additional cell surface marker without the need for a supplementary fluorochrome. METHODS… Expand
Single appointment insemination for heifers after prostaglandin or progestin synchronization of estrus.
Pregnancy rates to a single appointment insemination were compared in seven groups of beef or dairy heifers following estrus synchronization with the prostaglandin F(2a) product, cloprostenol, versus… Expand