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Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by α2‐adrenoceptors in the presence of experimental colitis
This study investigates the influence of intestinal inflammation on: (1) the control of intestinal neurotransmission and motility by prejunctional α2‐adrenoceptors and (2) the expression ofExpand
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Atorvastatin Prevents Endothelial Dysfunction in Mesenteric Arteries From Spontaneously Hypertensive Rats: Role of Cyclooxygenase 2–Derived Contracting Prostanoids
We investigated the effect of atorvastatin on cyclooxygenase (COX) contribution to endothelial dysfunction in spontaneously hypertensive rat (SHR) mesenteric resistance arteries. Atorvastatin (10Expand
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Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications.
The wide distribution of ATP and adenosine receptors as well as enzymes for purine metabolism in different gut regions suggests a complex role for these mediators in the regulation ofExpand
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Endothelial Dysfunction in Small Arteries of Essential Hypertensive Patients: Role of Cyclooxygenase-2 in Oxidative Stress Generation
Essential hypertensive patients show a reduced nitric oxide availability secondary to oxidative stress generation in peripheral microcirculation. Cyclooxygenase (COX) contributes to reduce nitricExpand
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Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats.
BACKGROUND & AIMS Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there haveExpand
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Differential Role of Cyclooxygenase 1 and 2 Isoforms in the Modulation of Colonic Neuromuscular Function in Experimental Inflammation
This study examines the role played by cyclooxygenase (COX) isoforms (COX-1 and -2) in the regulation of colonic neuromuscular function in normal rats and after induction of colitis byExpand
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Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage.
AIM This study investigated the mechanisms of protection afforded by the proton pump inhibitor lansoprazole against gastric injury induced by different non-steroidal anti-inflammatory drugs (NSAIDs)Expand
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Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) can be associated with severe adverse digestive effects. In clinical settings, proton pump inhibitors have proven to be effective inExpand
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Inhibition of Adenosine Deaminase Attenuates Inflammation in Experimental Colitis
Adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis and neutrophil functions. Drugs able to prevent adenosine catabolism could represent anExpand
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Adenosine deaminase in the modulation of immune system and its potential as a novel target for treatment of inflammatory disorders.
The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine modulation of inflammatory responses and protection of tissues from injuries. Adenosine exerts its modulatoryExpand
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