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S-adenosylmethionine: nothing goes to waste.
TLDR
S-adenosylmethionine (SAM or AdoMet) is a biological sulfonium compound known as the major biological methyl donor in reactions catalyzed by methyltransferases, which initiate many metabolic reactions and biosynthetic pathways by hydrogen-atom abstraction. Expand
Iron-Sulfur Cluster Biosynthesis
TLDR
A specific interaction between CyaY and IscS, a cysteine desulfurase participating in iron-sulfur cluster assembly is demonstrated for the first time, pointing toward a link between CyY and [Fe-S] cluster biosynthesis. Expand
SufE Transfers Sulfur from SufS to SufB for Iron-Sulfur Cluster Assembly*
TLDR
It is found that SufE in turn interacts with the SufB protein for sulfur transfer to that protein if SufC is present, which provides the first evidence of a novel site for Fe-S cluster assembly in theSufBCD complex. Expand
Biogenesis of Fe-S Cluster by the Bacterial Suf System
TLDR
It is demonstrated that SufE and SufS are both cystosolic as all members of the SUF system and this is the first example of a two-component cysteine desulfurase enzyme. Expand
NAD(P)H:flavin oxidoreductase of Escherichia coli. A ferric iron reductase participating in the generation of the free radical of ribonucleotide reductase.
TLDR
It is proposed that its complementing activity during radical generation involves participation in the reduction of the ferric iron center of protein B2/HU, which is then linked to the reoxidation of iron by oxygen. Expand
Resveratrol, a remarkable inhibitor of ribonucleotide reductase
TLDR
It is shown that Resveratrol is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans. Expand
Iron and activated oxygen species in biology: The basic chemistry
TLDR
A critical review concerning the chemical reactions involved when superoxide or hydrogen peroxide meet iron complexes is presented. Expand
Iron-Sulfur Cluster Assembly
TLDR
Results suggest that IscA is involved in ferredoxin cluster assembly and activation, an important function because a functional ferred toxin is required for maturation of other cellular Fe-S proteins. Expand
Cobalt Stress in Escherichia coli
TLDR
The biochemical and genetic experiments reported here demonstrate that iron-sulfur proteins are greatly affected in cobalt-treated Escherichia coli cells, and a model wherein cobalt competes out iron during synthesis of [Fe-S] clusters in metabolically essential proteins is proposed. Expand
Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis.
TLDR
This study identifies pABA, Yah1p, and Arh1p as three actors in Q(6) biosynthesis, a result that identifiespABA as a new precursor of Q( 6) and implies an additional NH(2)-to-OH conversion in Q’s biosynthesis. Expand
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