M. Foley

Publications66
h-index22
Citations2,771
Highly Influential Citations63
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Selective killing of cancer cells with a small molecule targeting stress response to ROS
Malignant transformation, driven by gain-of-function mutations in oncogenes and loss-of-function mutations in tumour suppressor genes, results in cell deregulation that is frequently associated with… Expand
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Systematic discovery of multicomponent therapeutics
Multicomponent therapies, originating through deliberate mixing of drugs in a clinical setting, through happenstance, and through rational design, have a successful history in a number of areas of… Expand
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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
Antimalarial drugs have thus far been chiefly derived from two sources—natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of… Expand
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Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays
Understanding the cellular function of a protein usually requires a means to alter the function. This is commonly done by mutating the gene encoding the protein (genetic approach). It can also be… Expand
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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of… Expand
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Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies
Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle robotnikinin. Analogues were prepared… Expand
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Statistical Reasoning in the Evaluation of Typological Diversity in Island Melanesia
This paper builds on a previous work in which we attempted to retrieve a phylogenetic signal using abstract structural features alone, as opposed to cognate sets, drawn from a sample of Island… Expand
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Loss of immunoreactivity for human calmodulin-like protein is an early event in breast cancer development.
Cell proliferation requires calmodulin, a protein that regulates calcium-dependent enzymes involved in signal transduction pathways in eukaryotic cells. Calmodulin-like protein (CLP) is found in… Expand
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An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.
An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and… Expand
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Synthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays
(−)-Shikimic acid, 3, was converted into both enantiomers of epoxycyclohexenol carboxylic acid, 7, which were attached to a solid support via a photocleavable linker. Tandem acylation−1,3-dipolar… Expand
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