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TRPV6 channel controls prostate cancer cell proliferation via Ca2+/NFAT-dependent pathways
The transient receptor potential channel, subfamily V, member 6 (TRPV6), is strongly expressed in advanced prostate cancer and significantly correlates with the Gleason >7 grading, being undetectableExpand
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Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores
Under resting conditions, the endoplasmic reticulum (ER) intraluminal free calcium concentration ([Ca2+]ER) reflects a balance between active uptake by Ca2+-ATPases and passive efflux via `leakExpand
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Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells
The molecular nature of calcium (Ca2+)-dependent mechanisms and the ion channels having a major role in the apoptosis of cancer cells remain a subject of debate. Here, we show that the recentlyExpand
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Novel Role of Cold/Menthol-sensitive Transient Receptor Potential Melastatine Family Member 8 (TRPM8) in the Activation of Store-operated Channels in LNCaP Human Prostate Cancer Epithelial Cells*
Recent cloning of a cold/menthol-sensitive TRPM8 channel (transient receptor potential melastatine family member 8) from rodent sensory neurons has provided the molecular basis for the coldExpand
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Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function.
In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has emerged as a promising prognostic marker and putative therapeutic target in prostate cancer (PCa). However,Expand
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Passive calcium leak via translocon is a first step for iPLA2‐pathway regulated store operated channels activation
Calcium concentration within the endoplasmic reticulum (ER) plays an essential role in cell physiopathology. One of the most enigmatic mechanisms responsible for Ca2+ concentration in the ER isExpand
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TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma.
Aberrant keratinocyte differentiation is considered to be a key mechanism in the onset of hyperproliferative dermatological diseases, including basal cell carcinoma (BCC). It is, therefore, vital toExpand
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Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells.
One major clinical problem with prostate cancer is the cells' ability to survive and proliferate upon androgen withdrawal. Because Ca2+ is central to growth control, understanding the mechanisms ofExpand
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PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression
Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic indicator, the naturalExpand
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Insights into Ca2+ homeostasis of advanced prostate cancer cells.
Prostate cancer is the second cancer-related cause of death. Nowadays, the aim of treatments is to decrease the effects of androgens on this organ. Unfortunately, over time, patients develop anExpand
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