• Publications
  • Influence
Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2
ABSTRACT Human CD81 has been previously identified as the putative receptor for the hepatitis C virus envelope glycoprotein E2. The large extracellular loop (LEL) of human CD81 differs in four aminoExpand
  • 236
  • 15
Diverse Hepatitis C Virus Glycoproteins Mediate Viral Infection in a CD81-Dependent Manner
ABSTRACT We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor forExpand
  • 194
  • 11
Virus-encoded proteinases of the picornavirus super-group.
  • M. Ryan, M. Flint
  • Biology, Medicine
  • The Journal of general virology
  • 1 April 1997
IP: 54.70.40.11 On: Sat, 03 Aug 2019 19:03:23 Journal of General Virology (1997), 78, 699–723. Printed in Great Britain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Expand
  • 242
  • 10
  • PDF
Functional Analysis of Cell Surface-Expressed Hepatitis C Virus E2 Glycoprotein
ABSTRACT Hepatitis C virus (HCV) glycoproteins E1 and E2, when expressed in eukaryotic cells, are retained in the endoplasmic reticulum (ER). C-terminal truncation of E2 at residue 661 or 715Expand
  • 195
  • 9
  • PDF
The cleavage activities of aphthovirus and cardiovirus 2A proteins.
The primary 2A/2B polyprotein cleavage of aphtho-and cardioviruses is mediated by their 2A proteins cleaving C-terminally. Whilst the aphthovirus 2A region is only 16 aa (possibly 18 aa) long, theExpand
  • 173
  • 7
  • PDF
Functional Characterization of Intracellular and Secreted Forms of a Truncated Hepatitis C Virus E2 Glycoprotein
ABSTRACT The E2 protein of hepatitis C virus (HCV) is believed to be a virion surface glycoprotein that is a candidate for inclusion in an antiviral vaccine. A truncated soluble version of E2 hasExpand
  • 118
  • 5
  • PDF
Virus-encoded proteinases of the Flaviviridae.
IP: 54.70.40.11 On: Fri, 28 Dec 2018 07:38:07 Journal of General Virology (1998), 79, 947–959. Printed in Great Britain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Expand
  • 70
  • 5
  • PDF
The role of the hepatitis C virus glycoproteins in infection
HCV encodes two glycoproteins, E1 and E2, that are believed to be exposed on the surface of virions. These molecules are likely to be involved in viral interactions with the host immune response andExpand
  • 96
  • 2
Production of interleukin-12 as a self-processing 2A polypeptide.
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-linked subunits (p40 and p35) encoded by separate genes. We used the apparent autocleavage property of a 2A peptide fromExpand
  • 47
  • 2
The C-terminal region of the hepatitis C virus E1 glycoprotein confers localization within the endoplasmic reticulum.
Expression of the hepatitis C virus glycoprotein E1 in cultured cells localizes it to the endoplasmic reticulum, suggesting that E1 contains a signal mediating retention. Fusion of the C-terminalExpand
  • 48
  • 2