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Nonenzymatic Glucosylation of Low-Density Lipoprotein Alters Its Biologic Activity
TLDR
Since, like other plasma proteins, LDL undergoes glucosylation in diabetes, its turnover and sites of catabolism may differ from normal and this may be relevant to the accelerated atherosclerosis of diabetes. Expand
Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine.
TLDR
Modifications of homologous LDL or albumin, other than addition of carbohydrate, would also render these proteins immunogenic in guinea pigs, but derivatization of lysine residues of guinea pig LDL oralbumin by carbamylation, acetylations, ethylation or even methylation rendered them immunogenic. Expand
Cholestyramine-induced changes in low density lipoprotein composition and metabolism. I. Studies in the guinea pig.
TLDR
The studies show that the effects of bile sequestration are complex and that the compositional changes produced have profound metabolic consequences and the implications for interpretation of LDL turnover studies are discussed. Expand
Nonenzymatic glucosylation of homologous low density lipoprotein and albumin renders them immunogenic in the guinea pig.
TLDR
The data suggest that nonenzymatic glucosylation of proteins could lead to autoantibody production and the formation of immune complexes in diabetic plasma and tissues. Expand
Autoantibodies to glucosylated proteins in the plasma of patients with diabetes mellitus.
TLDR
The data suggest that nonenzymatic glucosylation of plasma or structural proteins may render them immunogenic and result in production of autoantibodies that recognize not only the particular immunogen but also many other glucOSylated proteins, including glucosyated tissue proteins. Expand
Nonenzymatic Glucosylation of High-Density Lipoprotein Accelerates Its Catabolism in Guinea pigs
TLDR
With increasing amounts of glucose incorporated there was a proportionate increase in the rate of clearance of glcHDL when injected intravenously into guinea pigs, which may be relevant to the decreased HDL levels observed in diabetic subjects. Expand
Purification and properties of N-Ribosyladenine ribohydrolase from potato leaves
Abstract N -Ribosyladenine ribohydrolase, an enzyme that catalyzes the hydrolytic cleavage of adenosine in potato leaves, was extracted and purified 163-fold. Chromatography of the partially purifiedExpand
Rapid Publication Nonenzymatic Glucosylation of High-Density Lipoprotein Accelerates Its Catabolism in Guinea
SUMMARY Nonenzymatic glucosylation of lysine residues of high-density lipoprotein (HDL) was shown to occur in vitro. Most of the incorporated glucose was localized to apoprotein A-l, but otherExpand