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Relationship between subjective effects of cocaine and dopamine transporter occupancy
Cocaine is believed to work by blocking the dopamine transporter (DAT) and thereby increasing the availability of free dopamine within the brain1–4. Although this concept is central to currentExpand
Utility of subjective-effects measurements in assessing abuse liability of drugs in humans.
Estimates of the likelihood that a drug will be abused have generally been based on the subjective effects engendered by that drug. With the development of standardized subjective effectsExpand
The pharmacology of cocaine related to its abuse.
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine.
OBJECTIVE Dopamine is an important mediator of the reinforcing effects of cocaine, and alterations in dopamine function might be involved in cocaine dependence. The goals of the present study were toExpand
Cocaine self-administration in humans.
Studies are described in which normal healthy volunteers were tested with a wide range of intravenous doses of cocaine of d-amphetamine. Physiological measurements included heart rate,Expand
Satiety after preloads with different amounts of fat and carbohydrate: implications for obesity.
High intake of dietary fat may be key in both the etiology and maintenance of obesity. Because a reduction in the proportion of energy derived from fat will be accompanied by an increase in theExpand
Smoked and intravenous cocaine in humans: acute tolerance, cardiovascular and subjective effects.
Ten healthy adult male research volunteers with histories of smoked and i.v. cocaine use participated in four daily sessions. After resting base line, subjects received the same cocaine dose twiceExpand
Comparison of smoked marijuana and oral Δ9-tetrahydrocannabinol in humans
Abstract Rationale. Although smoked marijuana contains at least 60 cannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) is presumed to be the cannabinoid primarily responsible for many marijuana-relatedExpand
Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior
Striatal dopamine D2 receptors have been implicated in the neurobiology of cocaine addiction. Previous imaging studies showed reduced striatal D2 receptor availability in chronic cocaine abusers, andExpand
Effects of Acute Smoked Marijuana on Complex Cognitive Performance
Although the ability to perform complex cognitive operations is assumed to be impaired following acute marijuana smoking, complex cognitive performance after acute marijuana use has not beenExpand