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Prostate cancer in a transgenic mouse.
The establishment of breeding lines of transgenic mice that reproducibly develop prostate cancer provides an animal model system to study the molecular basis of transformation of normal prostatic cells and the factors influencing the progression to metastatic prostate cancer. Expand
Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
It is found that loss of Math1 leads to depletion of goblet, enteroendocrine, and Paneth cells without affecting enterocytes, and this suggests that secretory cells (goblet,Enteroendocrin, andPaneth cells) arise from a common progenitor that expresses Math1, whereas absorptive cells (enterocytes) arose from a progenitors that isMath1-independent. Expand
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Findings indicate that previous observations concerning Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem Cells in a tissue with a low rate of spontaneous proliferation. Expand
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
It is reported that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Expand
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome
Mice lacking the imprinted Cdk inhibitor p57KIP2 have altered cell proliferation and differentiation, leading to abdominal muscle defects; cleft palate; endochondral bone ossification defects withExpand
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
The results demonstrate that the Hippo signaling pathway is a critical regulator of mammalian liver growth and a potent suppressor of liver tumor formation. Expand
Cell fusion is the principal source of bone-marrow-derived hepatocytes
It is concluded that hepatocytes derived form bone marrow arise from cell fusion and not by differentiation of haematopoietic stem cells. Expand
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
This system provides a robust platform to produce high-quality human hepatocytes for tissue culture and may be useful for testing the toxicity of drug metabolites and for evaluating pathogens dependent on human liver cells for replication. Expand
Müllerian-inhibiting substance function during mammalian sexual development
It is suggested that eliminating the presumptive female reproductive tract in male fetuses facilitates fertility and that in testes MIS is a negative regulator of Leydig cell proliferation. Expand
The origin and liver repopulating capacity of murine oval cells
It is concluded that hepatic oval cells do not originate in bone marrow but in the liver itself, and that they have valuable properties for therapeutic liver repopulation. Expand