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Extracellular Brain Glucose Levels Reflect Local Neuronal Activity: A Microdialysis Study in Awake, Freely Moving Rats
Abstract: The relationship between brain extracellular glucose levels and neuronal activity was evaluated using microdialysis in awake, freely moving rats. The sodium channel blocker tetrodotoxin andExpand
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Continuous Monitoring of Extracellular Glucose Concentrations in the Striatum of Freely Moving Rats with an Implanted Glucose Biosensor
Abstract: We have used a glucose oxidase‐based sensor implanted in the striatum of freely moving rats to determine the concentration of extracellular glucose in two distinct ways. With a modificationExpand
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The role of lactate in brain metabolism
  • M. Fillenz
  • Medicine, Biology
  • Neurochemistry International
  • 1 November 2005
According to the astrocyte-neurone-lactate shuttle (ANLS) hypothesis, activated neurones use lactate released by astrocytes as their energy substrate. The hypothesis, based largely on in vitroExpand
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Physiological Stimulation Increases Nonoxidative Glucose Metabolism in the Brain of the Freely Moving Rat
Abstract: The effects of mild stress on nonoxidative glucose metabolism were studied in the brain of the freely moving rat. Extracellular lactate levels in the hippocampus and striatum were monitoredExpand
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Stimulated release of lactate in freely moving rats is dependent on the uptake of glutamate.
1. Physiological stimulation of neuronal activity induces an increase in extracellular lactate. Experiments were designed to determine the role of the reuptake of neuronally released glutamate inExpand
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In vivo determination of extracellular brain ascorbate
A quantitative method consisting of the modification of the zero net flux technique was used to determine the extracellular concentration of ascorbate. A carbon paste electrode (CPE) held at constantExpand
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The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study.
1. This study is concerned with the supply of metabolic substrates for neuronal metabolism. Experiments were carried out to investigate whether mechanisms demonstrated in cultured astrocytes alsoExpand
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Lactate reduces glutamate‐induced neurotoxicity in rat cortex
Experiments were carried out to test the hypothesis that lactate reduces the neurotoxicity of glutamate in vivo. MAP2 immunohistochemistry was used to measure lesion size, and microdialysis toExpand
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Measurement of brain tissue oxygen at a carbon paste electrode can serve as an index of increases in regional cerebral blood flow
Simultaneous monitoring of tissue O(2) and regional cerebral blood flow (rCBF) was performed in the striatum of freely-moving rats. Differential pulse amperometry and constant potential amperometryExpand
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The determination of the extracellular concentration of brain glutamate using quantitative microdialysis
Quantitative microdialysis with two enzyme-based assays was used to determine the extracellular concentration of glutamate in the striatum of freely moving rats. From the difference between infusedExpand
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