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Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells.
Since macrophages constitute the major site of liposome localization after parenteral administration and play an important role in the control of the immune system, cationic liposomes should be used with caution to deliver gene or antisense oligonucleotide to mammalian cells.
Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells
The results indicate that MCC directly effects bladder cancer cells by inhibiting cellular proliferation through the induction of apoptosis, and has the potential for an indirect anti-cancer activity by stimulating cancer-infiltrating monocytes/macrophages to synthesize IL-12.
A Two‐Tier Polymerase Chain Reaction Direct Sequencing Method for Detecting and Typing Human Papillomaviruses in Pathological Specimens
The two-tier PCR-DS was adopted by the authors as the current method of choice for HPV diagnosis with ultimate sequence precision.
Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population.
The activity of cytochrome oxidase (CO), the terminal enzyme of the mitochondrial electron transport chain, has been reported to be lower in the brains of Alzheimer disease (AD) patients. This
cDNA sequence and homologies of the "57-kDa" nucleotide-binding subunit of the vacuolar ATPase from Arabidopsis.
Comparison of protein sequences shows the 57-kDa subunit from Arabidopsis to be nearly identical with the corresponding subunit in Neurospora vacuolar membrane H+-ATPase, very similar to the beta subunit of the archaebacterium Sulfolobus, and slightly, but nevertheless significantly, homologous to the alpha and beta subunits of the F0F1- ATPases.
Influence of Surface Properties at Biodegradable Microsphere Surfaces: Effects on Plasma Protein Adsorption and Phagocytosis
These results demonstrate that spray-dried PEG-containing microspheres can be manufactured and that an appropriate concentration of this excipient in microsphere results in decreased phagocytosis.
Mechanism and Function of Monoclonal Antibodies Targeting Siglec-15 for Therapeutic Inhibition of Osteoclastic Bone Resorption*
It is established that Siglec-15 antibodies target osteoclasts in vivo and reveal a likely mechanism of action, and monoclonal antibodies induce rapid internalization, lysosomal targeting, and degradation of SigleC-15 by inducing receptor dimerization.
Pro‐inflammatory activity of contaminating DNA in hyaluronic acid preparations
It is clear from this study that HA preparations can induce the synthesis of pro‐inflammatory cytokines by monocytes, and the presence of pro-inflammatory DNA in HA preparations should be evaluated before its use, not only for the treatment of patients with inflammatory disorders, but also before many other applications.
Secretagogues cause a preferential discharge of large size granules in rat pancreas.
The present results strongly support the views that secretagogues cause the preferential release of large size granules and favor the formation of smallsize granules in exocrine pancreas of fasted or stimulated rats.
Major limitations in the use of cationic liposomes for DNA delivery
Liposomal vectors formulated with cationic lipids and the fusogenic phospholipid dioleyolphosphatidylethanolamine (DOPE) are usually used to target DNA inside mammalian cells. Since macrophages