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Adaptive evolution by mutations in the FLO11 gene.
It is determined that the capability to form a self-supporting biofilm at the liquid surface is largely dependent on two changes in the FLO11 gene, which results in dramatic increase in cell surface hydrophobicity, which confers these yeasts the ability to float by surface tension, an adaptive mechanism to gain direct access to oxygen within oxygen-poor liquid environments. Expand
Coding repeat instability in the FLO11 gene of Saccharomyces yeasts
It is reported here that, under optimal laboratory conditions, the repeats domain of the FLO11 gene in these wild yeasts is extremely unstable and variations in the number of intragenic repeats but also the abundance and/or distribution of the different repetitive units may have phenotypic and evolutionary implications. Expand
APHE-1and APHE-2exhibited in vitro antitumor activity against tumor cell lines of mice and human origin. Moreover, these antibiotics showed activity against Gram-positive bacteria, filamentous fungiExpand
APHE-1 and APHE-2, two new antimicrobial and cytotoxic antibiotics. II. Physico-chemical properties and structure elucidation.
Two new pyrazolo-isoquinolinone antibiotics, APHE-1 andAPHE-2, have been isolated from the culture filtrate and mycelia of Streptoverticillium griseocarneum NCIMB 40447 by elemental analysis, NMR and mass spectra. Expand
APHE-1 and APHE-2, two new antimicrobial and cytotoxic antibiotics. I. Taxonomy, fermentation, isolation and biological activity.
APHE-1 and APHE-2 are two new antibiotics produced by Streptoverticillium griseocarneum NCIMB 40447. They exhibited a remarkable cytotoxic activity against several tumor cell lines from differentExpand