M. Ferguson

Publications184
h-index48
Citations10,209
Highly Influential Citations491
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Palate development.
TLDR
Using such an approach, it is possible to go from a morphological description of palate development to a cellular analysis of the mechanisms involved and then to identification of candidate genes that may be important for screening and diagnosis of cleft palate.
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East African Mammals. An Atlas of Evolution in Africa
Pathogenesis of cleft palate in TGF-beta3 knockout mice.
TLDR
The results suggest that TGF-beta3 may regulate palatal fusion by inducing filopodia on the outer cell membrane of the palatal medial edge epithelia prior to shelf contact, and raises interesting potential therapeutic strategies to prevent and treat embryonic cleft palate.
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Transforming growth factor-beta 3 is required for secondary palate fusion.
TLDR
This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
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Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration
TLDR
The challenge is to identify the factors and cytokines expressed during regeneration and incorporate them to create a smart matrix for use in a skin equivalent, and recent advances in the use of DNA microarray and proteomic technology are likely to aid the identification of such molecules.
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Transforming growth factor–β3 is required for secondary palate fusion
TLDR
This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
View on Nature
Medial edge epithelial cell fate during palatal fusion.
TLDR
It is demonstrated that MEE cells die and transform into mesenchyme during palatal fusion and that dead cells are phagocytosed by macrophages, revealing that TGF-beta(3) has an important role as an inducer of apoptosis duringPalatal fusion.
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Reproductive biology and embryology of the crocodilians. IN: Gans, Billett and Maderson, Biology ofthe Reptilia
Physiological effects of incubation temperature on embryonic development in reptiles and birds
TLDR
Incubation temperature determines sex in many species of reptile and also affects the pigmentation pattern of hatchlings, post-hatching growth rates and moulting cycles as well as thermoregulatory and sexual behaviour patterns.
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TGF-beta(3)-induced chondroitin sulphate proteoglycan mediates palatal shelf adhesion.
TLDR
It is concluded that the expression of CSPG on the apical surface of MEE cells is a key factor in palatal shelf adhesion and that this expression is regulated by TGF-beta(3).
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