• Publications
  • Influence
Scar-free healing: from embryonic mechanisms to adult therapeutic intervention.
  • M. Ferguson, S. O'Kane
  • Medicine, Biology
    Philosophical transactions of the Royal Society…
  • 29 May 2004
TLDR
Scar-improving drugs could have widespread benefits and prevent complications in several tissues, e.g. prevention of blindness after scarring due to eye injury, facilitation of neuronal reconnections in the central and peripheral nervous system by the elimination of glial scarring, restitution of normal gut and reproductive function by prevents strictures and adhesions after injury to the gastrointestinal or reproductive systems, and restoration of locomotor function by preventing scarring in tendons and ligaments.
Visual Analogue Scale Scoring and Ranking: A Suitable and Sensitive Method for Assessing Scar Quality?
TLDR
The authors have shown the visual analogue scale scar scoring and scar ranking methods to be consistent, reliable, valid, and feasible for scar assessment.
Regeneration of the ear after wounding in different mouse strains is dependent on the severity of wound trauma
TLDR
To investigate the changes in tissue architecture leading to ear wound closure, initial ear wounding studies with a 2‐mm clinical biopsy punch were performed on MRL/MpJ mice, by using C57BL/6 mice as a nonregenerative control strain, and a third strain of mouse, Balb/c, known to be a slow‐healing strain was introduced.
A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule.
TLDR
Chloroplasts are an attractive production platform for synthesizing recombinant human TGFβ3 and functional equivalence was demonstrated by near-identical dose-response curves showing the inhibition of mink lung epithelial cell proliferation.
Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars.
TLDR
The data support a possible role of T GFssRI and TGFssRII in combination with a certain TGFSS expression pattern as fibrosis-inducing factors in keloids.
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