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The Smc5-Smc6 DNA Repair Complex
Structural maintenance of chromosomes (SMC) proteins play fundamental roles in many aspects of chromosome organization and dynamics. The SMC complexes form unique structures with long coiled-coilExpand
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The Smc5-Smc6 DNA Repair Complex: Bridging of the SMC5-SMC6heads by the kleisin, Nse4 ...
Structural maintenance of chromosomes (SMC) proteins play fundamental roles in many aspects of chromosome organization and dynamics. The SMC complexes form unique structures with long coiled-coilExpand
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Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer
Significance Colorectal cancer patients often relapse due to resistance to chemotherapy. The tumor microenvironment is known to contribute to tumor aggressiveness and chemoresistance, but theExpand
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Roles of divalent metal ions in flap endonuclease–substrate interactions
Flap endonucleases (FENs) have essential roles in DNA processing. They catalyze exonucleolytic and structure-specific endonucleolytic DNA cleavage reactions. Divalent metal ions are essentialExpand
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Immobilization of Lipases on Alkyl Silane Modified Magnetic Nanoparticles: Effect of Alkyl Chain Length on Enzyme Activity
Background Biocatalytic processes often require a full recycling of biocatalysts to optimize economic benefits and minimize waste disposal. Immobilization of biocatalysts onto particulate carriersExpand
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Direct observation of DNA threading in flap endonuclease complexes
Maintenance of genome integrity requires that branched nucleic acid molecules be accurately processed to produce double-helical DNA. Flap endonucleases are essential enzymes that trim such branchedExpand
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Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding
Previous structural studies on native T5 5′ nuclease, a member of the flap endonuclease family of structure-specific nucleases, demonstrated that this enzyme possesses an unusual helical arch mountedExpand
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Paclitaxel-loaded micelles composed of folate-poly(ethylene glycol) and poly(γ-benzyl l-glutamate) diblock copolymer
Abstract In this study folate-poly(ethylene glycol) and poly(γ-benzyl l -glutamate) diblock copolymer (FEG) was synthesized and the FEG chemical structure was characterized by 1 H nuclear magneticExpand
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Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver
Abstract Molecular and microbiome studies were employed to uncover the mechanisms underlying the cholesterol lowering effects of RC alkaloids. Hyperlipidemic mice were treated with RC alkaloids forExpand
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High mobility group box 1 protein enhances polyethylenimine mediated gene delivery in vitro.
The relatively low efficiency of transgene expression is a major drawback of non-viral gene delivery systems despite it being a safer alternative for gene therapy. Modifications of non-viral carriersExpand
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