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Mechanisms underlying development of visual maps and receptive fields.
A major goal now is to determine how axon guidance cues and a growing list of other molecules cooperate with spontaneous and visually evoked activity to give rise to the circuits underlying precise receptive field tuning and orderly visual maps.
Mice Lacking Specific Nicotinic Acetylcholine Receptor Subunits Exhibit Dramatically Altered Spontaneous Activity Patterns and Reveal a Limited Role for Retinal Waves in Forming ON and OFF Circuits…
- A. Bansal, J. Singer, Bryan J. Hwang, Wei Xu, A. Beaudet, M. Feller
- BiologyThe Journal of Neuroscience
- 15 October 2000
It is demonstrated here that the neural substrate that generates waves in the mouse retina develops through three distinct stages, and that retinal waves mediated by nAChRs are involved in, but not required for, the development of neural circuits that define the ON and OFF sublamina of the inner plexiform layer.
Competition in retinogeniculate patterning driven by spontaneous activity.
Interocular competition driven by endogenous retinal activity determines the pattern of eye-specific connections from retina to LGN, demonstrating that spontaneous activity can produce highly stereotyped patterns of connections before the onset of visual experience.
Retinotopic Map Refinement Requires Spontaneous Retinal Waves during a Brief Critical Period of Development
Requirement for Cholinergic Synaptic Transmission in the Propagation of Spontaneous Retinal Waves
The results indicate that the major source of synaptic input to retinal ganglion cells is a system of cholinergic amacrine cells, whose activity is required for wave propagation in the developing retina.
Genetic Identification of an On-Off Direction- Selective Retinal Ganglion Cell Subtype Reveals a Layer-Specific Subcortical Map of Posterior Motion
Mechanisms underlying spontaneous patterned activity in developing neural circuits
This research suggests that developing neural circuits exhibit transient and tunable features that maintain a source of correlated activity during crucial stages of development.
Spontaneous patterned retinal activity and the refinement of retinal projections
Retinogeniculate Axons Undergo Eye-Specific Segregation in the Absence of Eye-Specific Layers
It is shown that after the first postnatal week, even in the absence of layers, retinothalamic axons segregate into an unlayered, patchy distribution of eye-specific regions, indicating that spontaneous neural activity may independently regulate eye- specific segregation and the formation of layers at the developing retin hypothalamic projection.
Transgenic Mice Reveal Unexpected Diversity of On-Off Direction-Selective Retinal Ganglion Cell Subtypes and Brain Structures Involved in Motion Processing
Two genetically identified populations of On-Off DSGCs are compared and it is found that although both populations are tuned for posterior motion, they can be distinguished by a variety of physiological and anatomical criteria.