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An updated view on the role of dopamine in myopia.
Early transcriptional changes of retinal and choroidal TGFbeta-2, RALDH-2, and ZENK following imposed positive and negative defocus in chickens.
TLDR
Imposed defocus triggers extensive transcriptional changes of ZENK in the retina, and of TGFbeta-2 and RALHD-2 in the choroid, which are consistent with a role in causing or controlling later changes in eye growth.
A microarray analysis of retinal transcripts that are controlled by image contrast in mice
TLDR
Investigating the changes in retinal mRNA expression after different periods of visual deprivation in mice demonstrated a pattern of differential transcriptional changes, even though differences in the retinal images were restricted to spatial features.
Insulin acts as a powerful stimulator of axial myopia in chicks.
TLDR
Its powerful myopiagenic effect, which is mostly due to its effects on the optics of the anterior segment of the eye, merits further investigation.
Effects of positive and negative lens treatment on retinal and choroidal glucagon and glucagon receptor mRNA levels in the chicken.
TLDR
The observed bidirectional regulation of glucagon mRNA in correlation with the sign of imposed defocus supports the idea that glucagon may act as a stop-and-go signal for eye growth.
Interactions of spatial and luminance information in the retina of chickens during myopia development.
TLDR
It was found that dopamine release was controlled by both spatial and luminance information and that the inputs of both could be scarcely separated.
Evidence for a potential role of glucagon during eye growth regulation in chicks
TLDR
It was shown that the amount of retinal glucagon mRNA increased during treatment with positive lenses, and it seems likely that these cells contribute to the visual regulation of ocular growth and that glucagon may act as a stop signal for eye growth.
Gene expression within the amacrine cell layer of chicks after myopic and hyperopic defocus.
TLDR
The targeted investigation of the ACL enabled the identification of several novel genes that may form part of the growth regulatory pathways of the eye, as there was limited overlap in the regulated genes observed within the ACL under both conditions.
Regulation of Egr-1, VIP, and Shh mRNA and Egr-1 protein in the mouse retina by light and image quality.
TLDR
In mice, the mRNA levels of VIP and Shh were not affected by form deprivation, but they were found to be regulated depending on the time of day, especially by transitions between light and darkness.
Microarray analysis of retinal gene expression in chicks during imposed myopic defocus
TLDR
Chick microarrays were used to screen for new retinal candidate genes that could be involved in the inhibition of ocular growth, and validated genes that were regulated only by myopic defocus may represent elements in a pathway generating a “stop-signal” for eye growth.
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