• Publications
  • Influence
An updated view on the role of dopamine in myopia.
A large body of data is available to support the hypothesis that dopamine (DA) is one of the retinal neurotransmitters involved in the signaling cascade that controls eye growth by vision. Initially,Expand
  • 187
  • 6
Early transcriptional changes of retinal and choroidal TGFbeta-2, RALDH-2, and ZENK following imposed positive and negative defocus in chickens.
PURPOSE Imposing defocus to the retina results in compensatory changes of axial eye growth. It is not clear which factors initially contribute to this process and whether they act on theExpand
  • 56
  • 5
  • PDF
Interactions of spatial and luminance information in the retina of chickens during myopia development.
Degrading the retinal image by frosted eye occluders produces elongated eyes and 'deprivation myopia' in a variety of animal models. The postulated retinal 'deprivation detector' is quite sensitiveExpand
  • 47
  • 4
A microarray analysis of retinal transcripts that are controlled by image contrast in mice
Purpose The development of myopia is controlled by still largely unknown retinal signals. The aim of this study was to investigate the changes in retinal mRNA expression after different periods ofExpand
  • 32
  • 4
Evidence for a potential role of glucagon during eye growth regulation in chicks.
Eye growth and refraction are regulated by visual processing in the retina. Until now, the messengers released by the retina to induce these changes are largely unknown. Previously, it was found thatExpand
  • 88
  • 3
Effects of positive and negative lens treatment on retinal and choroidal glucagon and glucagon receptor mRNA levels in the chicken.
PURPOSE It has been found in the chicken that the amount of retinal glucagon mRNA increases during treatment with positive lenses. Pharmacological studies support the idea that glucagon may act as aExpand
  • 56
  • 3
  • PDF
Insulin acts as a powerful stimulator of axial myopia in chicks.
PURPOSE In animal models, it has been shown that the retina can use the defocus of the projected image to control emmetropization. Glucagon may be involved in the sign of defocus detection, at leastExpand
  • 54
  • 3
Gene expression within the amacrine cell layer of chicks after myopic and hyperopic defocus.
PURPOSE. Ocular growth is regulated locally by signals produced in the retina. The highly heterogeneous nature of the retina may mask important changes in gene expression during global analysis. ThisExpand
  • 18
  • 3
  • PDF
Regulation of Egr-1, VIP, and Shh mRNA and Egr-1 protein in the mouse retina by light and image quality.
PURPOSE To analyze mRNA expression changes of Egr-1, VIP, and Shh under different light and treatment conditions in mice. The mRNA expression levels of the three genes and additionally the Egr-1Expand
  • 36
  • 2
  • PDF
Microarray analysis of retinal gene expression in chicks during imposed myopic defocus
Purpose The retina plays an important regulatory role in ocular growth. To screen for new retinal candidate genes that could be involved in the inhibition of ocular growth, we used chick microarraysExpand
  • 43
  • 2
  • PDF