Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.
- E. Clementi, G. Brown, M. Feelisch, S. Moncada
- BiologyProceedings of the National Academy of Sciences…
- 23 June 1998
The results suggest that, although NO may regulate cell respiration physiologically by its action on complex IV, long-term exposure to NO leads to persistent inhibition of complex I and potentially to cell pathology.
The use of nitric oxide donors in pharmacological studies
- M. Feelisch
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 20 July 1998
Compound selection is not a trivial issue and the investigator should be aware of the key properties and differences between various NO donor classes in order to avoid misinterpretation of experimental results.
Modulation of Nitrosative Stress by S-Nitrosoglutathione Reductase Is Critical for Thermotolerance and Plant Growth in Arabidopsis [W]
- Ung Lee, Chris Wie, B. Fernandez, M. Feelisch, E. Vierling
- Environmental ScienceThe Plant Cell Online
- 1 March 2008
The results expand the importance of GSNOR-regulated NO homeostasis to abiotic stress and plant development, and the heat sensitivity of both missense and null alleles is associated with increased NO species.
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
- P. Kleinbongard, A. Dejam, M. Kelm
- Biology, ChemistryFree Radical Biology & Medicine
- 1 October 2003
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
- T. Lauer, M. Preik, M. Kelm
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 16 October 2001
The results contradict the current paradigm that plasma NO3− and/or total NOx are generally useful markers of endogenous NO production and demonstrate that only NO2− reflects acute changes in regional eNOS activity and physiological levels of nitrite are vasodilator-inactive.
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
- N. Bryan, B. Fernandez, M. Feelisch
- BiologyNature Chemical Biology
- 18 September 2005
Mammalian tissues produce nitric oxide (NO) to modify proteins at heme and sulfhydryl sites, thereby regulating vital cell functions. The majority of NO produced is widely assumed to be neutralized…
The emerging biology of the nitrite anion
- M. Gladwin, A. Schechter, J. Lundberg
- BiologyNature Chemical Biology
- 1 November 2005
Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National…
Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase.
- M. Feelisch, E. Noack
- Biology, ChemistryEuropean Journal of Pharmacology
- 2 July 1987
The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators: Appropriate Choice of Exogenous NO Donors and Aspects of Preparation and Handling of Aqueous NO Solutions
- M. Feelisch
- Biology
- 1991
Nitrovasodilators are prodrugs of NO and thus principally suited to mimic endogenous NO activities and are increasing interest in using compounds capable of generating NO in situ.
On the Mechanism of NO Release from Sydnonimines
- M. Feelisch, J. Ostrowski, E. Noack
- BiologyJournal of Cardiovascular Pharmacology
- 1989
It is concluded that oxygen plays a key role in the decomposition of sydnonimines and thus in the formation of NO as their pharmacodynamically active principle.
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