• Publications
  • Influence
The use of nitric oxide donors in pharmacological studies
  • M. Feelisch
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 20 July 1998
Compound selection is not a trivial issue and the investigator should be aware of the key properties and differences between various NO donor classes in order to avoid misinterpretation of experimental results. Expand
Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.
The results suggest that, although NO may regulate cell respiration physiologically by its action on complex IV, long-term exposure to NO leads to persistent inhibition of complex I and potentially to cell pathology. Expand
Modulation of Nitrosative Stress by S-Nitrosoglutathione Reductase Is Critical for Thermotolerance and Plant Growth in Arabidopsis [W]
The results expand the importance of GSNOR-regulated NO homeostasis to abiotic stress and plant development, and the heat sensitivity of both missense and null alleles is associated with increased NO species. Expand
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
Evidence is provided for a uniform constitutive vascular NOS-activity across mammalian species by determining plasma nitrite concentration to be in a nanomolar range in a variety of species. Expand
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
  • T. Lauer, M. Preik, +4 authors M. Kelm
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 16 October 2001
The results contradict the current paradigm that plasma NO3− and/or total NOx are generally useful markers of endogenous NO production and demonstrate that only NO2− reflects acute changes in regional eNOS activity and physiological levels of nitrite are vasodilator-inactive. Expand
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Mammalian tissues produce nitric oxide (NO) to modify proteins at heme and sulfhydryl sites, thereby regulating vital cell functions. The majority of NO produced is widely assumed to be neutralizedExpand
On the Mechanism of NO Release from Sydnonimines
It is concluded that oxygen plays a key role in the decomposition of sydnonimines and thus in the formation of NO as their pharmacodynamically active principle. Expand
Methods in nitric oxide research
This book covers the methodologies associated with the chemistry, biochemistry, pharmacology, molecular biology, and therapeutic applications of nitric oxide (NO). In addition, specific methods forExpand
The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators: Appropriate Choice of Exogenous NO Donors and Aspects of Preparation and Handling of Aqueous NO Solutions
The endogenous formation of nitric oxide (NO) plays a key role in many bioregulatory systems inclunding the control of vascular tone, platelet aggregation, neutrotransmission, and macrophageExpand
Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase.
The release of nitric oxide from organic nitrates is examined by means of a difference-spectrophotometric method and it is found that the results correlated well with the extent of enzyme activation, suggesting both an enzymatic and a non-enzymatic mode of inhibition of enzyme activity does exist. Expand