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Roles of HMGA proteins in cancer
The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription… Expand
High level expression of the HMGI (Y) gene during embryonic development.
The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their… Expand
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
- D. D'Angelo, D. Palmieri, +7 authors A. Fusco
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 7 May 2012
CONTEXT MicroRNA (miRNA) are an important class of regulators of gene expression. Altered miRNA expression has been constantly found in human neoplasias and plays an important role in the process of… Expand
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFκB p65 protein expression
We have investigated the role of the NFκB complex in the process of thyroid carcinogenesis by analysing thyroid carcinoma cell lines. A significant increase in p65 NFκB mRNA and protein expression,… Expand
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas
Overexpression of the HMGA2 gene is a common feature of neoplastic cells both in experimental and human models. Intragenic and extragenic HMGA2 rearrangements responsible for HMGA2 gene… Expand
Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma
- G. Baldassarre, S. Battista, +7 authors A. Fusco
- Biology, Medicine
- Molecular and Cellular Biology
- 1 April 2003
ABSTRACT A drastic reduction in BRCA1 gene expression is a characteristic feature of aggressive sporadic breast carcinoma. However, the mechanisms underlying BRCA1 downregulation in breast cancer are… Expand
A Novel Member of the BTB/POZ Family, PATZ, Associates with the RNF4 RING Finger Protein and Acts as a Transcriptional Repressor*
- M. Fedele, G. Benvenuto, +10 authors L. Chiariotti
- Medicine, Biology
- The Journal of Biological Chemistry
- 17 March 2000
We have identified a novel human gene encoding a 59-kDa POZ-AT hook-zinc finger protein (PATZ) that interacts with RNF4, a mediator of androgen receptor activity, and acts as a transcriptional… Expand
HMGA and cancer.
Long-standing studies have clearly established that the architectural chromatinic proteins High Mobility Group A (HMGA) are among the most widely expressed cancer-associated proteins. Indeed, their… Expand
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.
Rearrangements of the HMGI-C gene have frequently been detected in human benign tumors of mesenchymal origin, including lipomas. The HMGI-C protein has three AT-hook domains and an acidic… Expand
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
HMGA2 gene amplification and overexpression in human prolactinomas and the development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role in pituitary… Expand