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Chlamydia trachomatis Disrupts N-Cadherin-Dependent Cell-Cell Junctions and Sequesters β-Catenin in Human Cervical Epithelial Cells
- W. Prozialeck, M. Fay, P. Lamar, C. Pearson, I. Sigar, K. Ramsey
- Biology, Medicine
- Infection and Immunity
- 1 May 2002
Results indicate that C. trachomatis causes the breakdown of the N-cadherin/β- catenin complex and that the organism can sequester β-catenin within the chlamydial inclusion. Expand
Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues
The data demonstrate no apparent decrease in CUL-5 expression in the breast cancer cell lines (MCF-7, MDA-MB-231) versus the breast epithelial cells (HMEC, MCF-10A), and the hypothesis that decreased expression of Cul-5 may play a role in breast tumorigenesis is supported. Expand
Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.
It is demonstrated that SCCL cells express not only vasopressin V1a receptors but also mRNAs and proteins representing normal V1b receptors and V2 receptors, which suggests that this peptide serves a multifaceted role in tumor physiology. Expand
Cadmium Nephrotoxicity Is Associated with Altered MicroRNA Expression in the Rat Renal Cortex
It is demonstrated that Cd significantly alters the miRNA expression profile in the renal cortex and raises the possibility that dysregulated miRNAs may play a role in the pathophysiology of Cd-induced kidney injury. Expand
Granulocytic differentiation of HL-60 promyelocytic leukemia cells is associated with increased expression of Cul5
- Shaneen S. Baxter, Lauren A. Carlson, A. Mayer, Mary L. Hall, M. Fay
- Biology, Medicine
- In Vitro Cellular & Developmental Biology…
Increased expression of multiple components of the Cul5-containing E3 ubiquitin ligase complex with ATRA treatment of HL-60 cells indicates that this complex may play an important role in granulocytic differentiation. Expand
MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R☆
This study shows MCF-7 breast cancer cells express mRNAs for all currently recognized vasopressin receptor subtypes (V1a, V1b, and V2) and demonstrates that normal sequences representing each receptor were present. Expand
Stimulatory action of calcium L-threonate on ascorbic acid uptake by a human T-lymphoma cell line.
Results indicate that calcium threonate and possibly other ascorbic acid metabolites have biological activity and potential pharmacological applications. Expand
Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
This is the first experimental evidence that domoic acid, at in vitro concentrations that are toxic to neuronal cells, can trigger a release of statistically significant amounts of TNF-α and MMP-9 by brain microglia. Expand
Comparison of the anti-scorbutic activity of L-ascorbic acid and Ester C in the non-ascorbate synthesizing Osteogenic Disorder Shionogi (ODS) rat.
EC rats had 3-4 times less, if any, scorbutic signs than AA rats, and has more available ascorbate activity/potency than AA, which is believed to be due to the facilitated transport of AAE into the cell by the threonate present in the EC product. Expand
Evidence for expression of vasopressin V2 receptor mRNA in human lung
The role for the V2 receptor in adult human lung is unknown at this time, but, as in the human kidney and lungs of fetal sheep, goats, and guinea pigs, this receptor may play a role in fluid balance. Expand