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Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.
OBJECTIVE This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives toExpand
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Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder.
OBJECTIVE Major depressive disorder is characterized by impaired reward processing, possibly due to dysfunction in the basal ganglia. However, few neuroimaging studies of depression haveExpand
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Major depressive disorder
Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleepExpand
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Diagnosis and definition of treatment-resistant depression
  • M. Fava
  • Psychology, Medicine
  • Biological Psychiatry
  • 15 April 2003
Treatment-resistant depression (TRD) typically refers to inadequate response to at least one antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence in clinicalExpand
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Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.
BACKGROUND After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective than switchingExpand
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Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report.
OBJECTIVE About half of outpatients with major depressive disorder also have clinically meaningful levels of anxiety. The authors conducted a secondary data analysis to compare antidepressantExpand
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Medication augmentation after the failure of SSRIs for depression.
BACKGROUND Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach. METHODSExpand
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Report by the ACNP Task Force on Response and Remission in Major Depressive Disorder
This report summarizes recommendations from the ACNP Task Force on the conceptualization of remission and its implications for defining recovery, relapse, recurrence, and response for clinicalExpand
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The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication.
CONTEXT Little is known about the epidemiology of intermittent explosive disorder (IED). OBJECTIVE To present nationally representative data on the prevalence and correlates of DSM-IV IED. DESIGNExpand
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Depression and public health: an overview.
Depressive disorders are a significant public health issue. They are prevalent, disabling, often chronic illnesses, which cause a high economic burden for society, related to both direct and indirectExpand
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