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Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization*
- Mei Zhang, S. Xuan, +8 authors T. Clemens
- Biology, Medicine
- The Journal of Biological Chemistry
- 15 November 2002
To examine the local actions of IGF signaling in skeletal tissue in a physiological context, we have used Cre-mediated recombination to disrupt selectively in mouse osteoblasts the gene encoding the… Expand
Structural and cellular assessment of bone quality of proximal femur.
Prevention of bone loss in renal transplant recipients: a prospective, randomized trial of intravenous pamidronate.
- M. Coco, D. Glicklich, +10 authors H. Malluche
- Journal of the American Society of Nephrology…
- 1 October 2003
Renal transplant recipients are at risk of developing bone abnormalities that result in bone loss and bone fractures. These are related to underlying renal osteodystrophy, hypophosphatemia, and… Expand
Essential Role of β-Catenin in Postnatal Bone Acquisition*
Mutations in the Wnt co-receptor LRP5 alter bone mass in humans, but the mechanisms responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt signaling pathway in… Expand
Renal bone disease 1990: an unmet challenge for the nephrologist.
A rational approach to the treatment of renal bone disease requires a basic understanding of: (1) the anatomic physiology of bone; (2) the pathophysiologic effects of renal failure on mineral… Expand
Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis.
Predictive value of plasma levels of bone Gla-protein (BGP) for bone histology was evaluated in 30 chronically dialyzed patients. All patients underwent bone biopsies and serum biochemical… Expand
Aluminum-related bone disease in mild and advanced renal failure: evidence for high prevalence and morbidity and studies on etiology and diagnosis.
- A. Smith, M. Faugere, K. Abreo, P. Fanti, B. Julian, H. Malluche
- American journal of nephrology
To study aluminum-related bone disease, bone biopsies and serum biochemical measurements were done in 97 patients on maintenance dialysis and in 100 patients with mild to moderate renal failure. Bone… Expand
1,25(OH)2D3 administration in moderate renal failure: a prospective double-blind trial.
This study represents the first randomized prospective, double-blind, placebo-controlled trial of the efficacy of 1,25(OH)2D3 on bone histology and serum biochemistry in patients with mild to… Expand
Bone changes occurring early after cessation of ovarian function in beagle dogs: A histomorphometric study employing sequential biopsies
- M. Faugere, R. Friedler, P. Fanti, H. Malluche
- Biology, Medicine
- Journal of bone and mineral research : the…
- 1 March 1990
The beagle dog model has been established by our laboratory as a useful animal model to study bone loss after cessation of ovarian function. Previously we demonstrated bone loss associated with an… Expand
The use of deferoxamine in the management of aluminium accumulation in bone in patients with renal failure.
Aluminum frequently accumulates in patients with end-stage renal failure. We investigated the value of long-term, intermittent infusions of deferoxamine for the removal of aluminium from bone in… Expand