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Alternative Splicing Controls Nuclear Translocation of the Cell Cycle-regulated Nek2 Kinase*
Alternative splicing provides an unusual mechanism for modulating Nek2 localization, enabling it to have both nuclear and cytoplasmic functions.
Identification of the human testis protein phosphatase 1 interactome.
Signaling mechanisms in mammalian sperm motility
This review describes and discusses the main signaling pathways involved in primary and hyperactivated motility, as well as the bioenergetic mechanisms necessary to produce energy to fuel sperm motility.
An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy.
- Mariana Q. Mesquita, Cristina J. Dias, Sara R D Gamelas, M. Fardilha, M. Neves, M. Faustino
- Biology, ChemistryAnais da Academia Brasileira de Ciencias
In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.
Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins.
Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility.
- M. Fardilha, S. Esteves, L. Korrodi-Gregório, S. Pelech, O. A. B. da Cruz e Silva, E. F. da Cruz e Silva
- BiologyMolecular human reproduction
- 1 August 2011
This review summarizes the known sperm-specific PP1-PIPs, involved in the acquisition of mammalian sperm motility, and the role of PP1/A-kinase anchoring protein complexes in sperm Motility is considered.
Alternatively Spliced Protein Variants as Potential Therapeutic Targets for Male Infertility and Contraception
- M. Fardilha, Wenjuan Wu, E. F. Cruz e Silva
- BiologyAnnals of the New York Academy of Sciences
- 1 December 2004
Both the previously known Nek2A isoform and the novel Nek2a‐T and NIPP1‐T variants appear to bind PP1γ2 in vitro (blot overlays) and in vivo by coexpression in yeast.
The power of the yeast two-hybrid system in the identification of novel drug targets: building and modulating PPP1 interactomes
- J. Silva, M. J. Freitas, Juliana Felgueiras, M. Fardilha
- BiologyExpert review of proteomics
- 4 March 2015
This review highlights the relevance of Y2H in the determination of PPIs, specifically phosphoprotein phosphatase 1 interactions, and its possible outcomes in pharmaceutical research.
Protein phosphatase 1α interacting proteins in the human brain.
- S. Esteves, Sara Domingues, O. A. B. da Cruz e Silva, M. Fardilha, E. F. da Cruz e Silva
- BiologyOmics : a journal of integrative biology
- 9 February 2012
An in-depth survey was taken to identify specific PP1α PIPs in human brain by a high-throughput Yeast Two-Hybrid approach, with a large protein interaction databases search performed to integrate with the results of the PP1 α Human Brain Yeast two-hybrid.
The Nuclear Envelope Protein, LAP1B, Is a Novel Protein Phosphatase 1 Substrate
A novel PP1 binding protein, the nuclear membrane protein lamina associated polypeptide 1B (LAP1B), which interacts with the DYT1 dystonia protein torsinA, which is identified as the REVRF motif at amino acids 55-59.