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Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes
Purpose: Nemorubicin (3′-deamino-3′-[2″(S)-methoxy-4″-morpholinyl]doxorubicin; MMDX) is an investigational drug currently in phase II/III clinical testing in hepatocellular carcinoma. A bioactivationExpand
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Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties.
Previous investigations indicate that some of the metabolites of the hemorheological agent pentoxifylline (PTX), namely 1-(5-hydroxyhexyl)-3,7-dimethylxanthine (M1),Expand
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In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes.
We recently demonstrated that nemorubicin (MMDX), an investigational antitumor drug, is converted to an active metabolite, PNU-159682, by human liver cytochrome P450 (CYP) 3A4. The objectives of thisExpand
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Lower Troncoso Eolian Bodies Identification in the Neuquen Basin, Argentina: A Different Approach and some Geological Implications
Lower Troncoso Member is one of the most important reservoirs within the Neuquen Basin, Argentina, where it hosts large amounts of reserves.
INVOLVEMENT OF MURINE CYTOCHROME P450 3A ENZYMES IN THE BIOACTIVATION OF METHOXYMORPHOLINYL DOXORUBICIN (NEMORUBICIN)
Background: Methoxymorpholinyl doxorubicin (nemorubicin; MMDX), a doxorubicin (DX) derivative bearing a methoxymorpholinyl group at position 3’ of the sugar moiety, is currently under clinicalExpand