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The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma.
TLDR
Vitamin D supplementation associated with asthma controllers could significantly improveFEV1 in mild to moderate persistent asthma after 24 weeks, and FEV1 was significantly better in the intervention group than the other group after24 weeks. Expand
Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency
TLDR
Further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents. Expand
Novel Patient with Late-Onset Familial Hemophagocytic Lymphohistiocytosis with STXBP2 Mutations Presenting with Autoimmune Hepatitis, Neurological Manifestations and Infections Associated with
TLDR
A patient is presented who suffered from hepatitis and atypical brain lesions and genetic studies revealed a homozygous mutation in the STXP2 gene; and thus, the diagnosis of FHL5 was confirmed. Expand
Fourth Update on the Iranian National Registry of Primary Immunodeficiencies: Integration of Molecular Diagnosis
TLDR
Among the genetically different categories of PID patients, the diagnostic rate was highest in defects in immune dysregulation and lowest in predominantly antibody deficiencies and mutations in the MEFV gene were the most frequent genetic disorder in this cohort. Expand
Aspirin desensitization for patients with aspirin-exacerbated respiratory disease: A randomized double-blind placebo-controlled trial.
TLDR
Symptom scores and medication needs of patients with AERD who have undergone AD were significantly lower compared to the placebo group after 6 months, and no significant difference was observed in serum concentration of IL-10, IFN-γ, and TGF-β between two groups neither at baseline nor at the end of study. Expand
HLA-DRB and HLA-DQ Genetic Variability in Patients with Aspirin-Exacerbated Respiratory Disease
TLDR
Results of this study suggest that HLA-DQB1*0302 and Hla-DRB1*04 and their related haplotypes are genes involved in predisposing patients to AERD, whereas HLA+DQB*0301 and HLA*1*011 have negative association with A ERD. Expand
Aspirin Hypersensitivity in Patients with Chronic Rhinosinusitis and Nasal Polyposis: Frequency and Contributing Factors
TLDR
Aspirin-exacerbated respiratory disease (AERD) is a syndrome frequently seen in patients with chronic rhinosinusitis and nasal polyposis (CRSwNP) and the frequency of ASA hypersensitivity and factors associated with it in patients in Tehran, Iran is determined. Expand
Multiple cancers in a patient with common variable immunodeficiency.
TLDR
The use of tau protein as a marker for the diagnosis of CreutzfeldtJakob disease and neurobiochemical markers of neuronal damage are related to early clinical course and long-term outcome in acute ischemic stroke. Expand
Spatial and Temporal Analysis of Dusty Days in Iran
Iran is one of the world's arid regions and exposed to dust particles in the air. This is important in spatial and temporal terms as well as the affects human health. In this paper a day when due toExpand
A gain-of-function mutation of STAT1: A novel genetic factor contributing to chronic mucocutaneous candidiasis.
TLDR
A 33-year-old man who experienced chronic refractory candidiasis, recurrent otitis media, and pneumonia resulting in bronchiectasis, severe oral and esophageal candidiases with strictures associated with hypothyroidism and immune hemolytic anemia is described. Expand
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