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CathaCyc, a metabolic pathway database built from Catharanthus roseus RNA-Seq data.
The medicinal plant Madagascar periwinkle (Catharanthus roseus) synthesizes numerous terpenoid indole alkaloids (TIAs), such as the anticancer drugs vinblastine and vincristine. The TIA pathwayExpand
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Cutting-Edge Issues in Celiac Disease and in Gluten Intolerance
Celiac disease (CD) is a gluten-dependent immune-mediated disease with a prevalence in the general population estimated between 0.3% and 1.2%. Large-scale epidemiological studies have shown that onlyExpand
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The transcription factor bZIP14 regulates the TCA cycle in the diatom Phaeodactylum tricornutum
Diatoms are amongst the most important marine microalgae in terms of biomass, but little is known concerning the molecular mechanisms that regulate their versatile metabolism. Here, the pennateExpand
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Emerging Technologies in Algal Biotechnology: Toward the Establishment of a Sustainable, Algae-Based Bioeconomy
Mankind has recognized the value of land plants as renewable sources of food, medicine, and materials for millennia. Throughout human history, agricultural methods were continuously modified andExpand
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Extrachromosomal genetic engineering of the marine diatom Phaeodactylum tricornutum enables the heterologous production of monoterpenoids.
Geraniol is a commercially-relevant plant-derived monoterpenoid that is a main component of rose essential oil and used as insect repellent. Geraniol is also a key intermediate compound in theExpand
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Metabolic Engineering Strategies in Diatoms Reveal Unique Phenotypes and Genetic Configurations With Implications for Algal Genetics and Synthetic Biology
Diatoms are photosynthetic microeukaryotes that dominate phytoplankton populations and have increasing applicability in biotechnology. Uncovering their complex biology and elevating strains toExpand
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Enhancing diatom lipid production through metabolic engineering, first phases
The biological productiv ity o f marine heterokonts, and specifically diatoms, is one o f the major contributors to the marine foodweb. In growth lim iting conditions diatoms store energy and carbonExpand
Differential expression of a model diatom in the early phases of lipid accumulation
Diatoms are unicellular algae that contribute tremendously to the primary production of aquatic ecosystems. Their main primary storage products are lipids. We work with the main model species forExpand
The early nitrogen starvation response of the diatom Phaeodactylum tricornutum
In th is study we investigated the transcrip tom ic and metabolic response o f Phaeodactylum trico rnu tum to nitrogen starvation and other stresses during the firs t 24 hours. P. tr ico rnu tum is aExpand