M. F. Varela

Publications37
h-index18
Citations824
Highly Influential Citations31
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Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily
Bacterial infections pose a serious public health concern, especially when an infectious disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can compromise the… Expand
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Molecular biology of the lactose carrier of Escherichia coli.
3. Introduction 22 1.1. The chemiosmotic hypothesis 22 General features of the lactose carrier 22 2.1. Assays for transport 22 2.2. Discovery and demonstration of lactose-proton cotransport 22 2.3.… Expand
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The Food Production Environment and the Development of Antimicrobial Resistance in Human Pathogens of Animal Origin
Food-borne pathogens are a serious human health concern worldwide, and the emergence of antibiotic-resistant food pathogens has further confounded this problem. Once-highly-efficacious antibiotics… Expand
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Biochemistry of Bacterial Multidrug Efflux Pumps
Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow… Expand
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LmrS Is a Multidrug Efflux Pump of the Major Facilitator Superfamily from Staphylococcus aureus
ABSTRACT A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the… Expand
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Mutational analysis and molecular modelling of an amino acid sequence motif conserved in antiporters but not symporters in a transporter superfamily.
Elements of a 'G X8 G X3 G P X2 G G' amino acid sequence motif were conserved in the fifth predicted membrane-spanning domains of 31 antiporters, but none of 27 symporters or uniporters that together… Expand
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Identification, cloning, and functional characterization of EmrD-3, a putative multidrug efflux pump of the major facilitator superfamily from Vibrio cholerae O395
A putative multidrug efflux pump, EmrD-3, belonging to the major facilitator superfamily (MFS) of transporters and sharing homology with the Bcr/CflA subfamily, was identified in Vibrio cholerae… Expand
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Inhibition of the multidrug efflux pump LmrS from Staphylococcus aureus by cumin spice Cuminum cyminum
Staphylococcus aureus is a serious causative agent of infectious disease. Multidrug-resistant strains like methicillin-resistant S. aureus compromise treatment efficacy, causing significant morbidity… Expand
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EmmdR, a new member of the MATE family of multidrug transporters, extrudes quinolones from Enterobacter cloacae
We cloned a gene, ECL_03329, from the chromosome of Enterobacter cloacae ATCC13047, using a drug-hypersensitive Escherichia coli KAM32 cell as the host. We show here that this gene, designated as… Expand
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SugE, a New Member of the SMR Family of Transporters, Contributes to Antimicrobial Resistance in Enterobacter cloacae
ABSTRACT We cloned a gene, sugE, from the chromosome of Enterobacter cloacae ATCC 13047. Analysis of the susceptibilities of the sugE-containing strain (Escherichia coli KAM32/pSUGE28) and… Expand
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