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PLGA microspheres for the ocular delivery of a peptide drug, vancomycin using emulsification/spray-drying as the preparation method: in vitro/in vivo studies.
The aim of this study was an in vitro/in vivo investigation on poly(lactide-co-glycolide) (PLGA) microspheres as carriers for the topical ocular delivery of a peptide drug vancomycin (VA). TheExpand
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Evaluation of ocular permeation enhancers: In vitro effects on corneal transport of four β-blockers, and in vitro/in vivo toxic activity
Abstract The efficacy and toxicity of a series of prospective ocular penetration enhancers (benzalkonium chloride, EDTA, non-ionic surfactants, surface-active heteroglycosides and bile salts) wasExpand
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Ocular inserts for topical delivery
Abstract In spite of extensive pharmacological and clinical data pointing to the usefulness and advantages of solid devices for topical drug delivery to the eye, liquid, and to a smaller extent,Expand
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Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin.
Purpose of the present investigation was to evaluate six terpene-containing essential oils for their capacity to promote permeation of estradiol (ES) through hairless mouse skin in vitro. Tests onExpand
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Polymer effects on ocular bioavailability: the influence of different liquid vehicles on the mydriatic response of tropicamide in humans and in rabbits
Five viscous polymeric vehicles containing 0.2% tropicamide were tested for mydriatic activity in humans and in rabbits. The polymers were carboxymethylcellulose (CMC), low molecular weightExpand
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In Vitro Transungual Permeation of Ciclopirox from a Hydroxypropyl Chitosan-Based, Water-Soluble Nail Lacquer
Commercial antimycotic nail lacquers are commonly based on water-insoluble resins. The present study was aimed at evaluating a novel, experimental nail lacquer (P-3051, Polichem SA, Lugano,Expand
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A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol: effect on intraocular pressure in rabbits.
delta 8-Tetrahydrocannabinol (delta 8-THC), a known antiglaucoma lipophilic drug, was incorporated in a submicron emulsion for ocular administration. The mean droplet size of the emulsion was 130 +/-Expand
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Cytotoxicity of potential ocular permeation enhancers evaluated on rabbit and human corneal epithelial cell lines.
A series of prospective ocular permeation enhancers, benzalkonium chloride (BAC), cetylpyridinium chloride (CPC), ethylenediaminetetraacetic acid (EDTA), polyoxyethylene (20) stearyl ether (PSE) andExpand
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Increased corneal hydration induced by potential ocular penetration enhancers: assessment by differential scanning calorimetry (DSC) and by desiccation.
The corneal toxicity of some surfactants of possible use as ocular penetration enhancers was investigated by measuring their effect on hydration of rabbit corneas 'in vitro'. The tested substancesExpand
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Evaluation of muco-adhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid
Abstract A series of prospective ophthalmic vehicles based on hyaluronic acid (HA) and on polyacrylic acid (PAA) (solutions, gels, matrices prepared by compression and by casting) containingExpand
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