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[15-Hydroxyprostaglandin dehydrogenase from human placenta. 1. Isolation and characterization].
TLDR
The protein in the final preparation steps showed neither alcohol dehydrogenase, NAD reductase, nor NADH oxidase activity, nor enzymatic conversion of prostaglandin or 15-oxoprostaglandIn in the absence of NAD and NADH, so no evidence for the exitstence of isoenzymes was obtained.
[15-Hydroxyprostaglandin dehydrogenase from human placenta, II. Steady state kinetics and influence of prostaglandin F2alpha analogues (author's transl)].
TLDR
The initial rate and inhibition patterns obtained indicate that the reaction follows kinetically an ordered Bi Bi mechanism and is likely to have biological significance.
Molecular and kinetic properties of 15-hydroxyprostaglandin dehydrogenase (PG-15-HDH) from human placenta.
TLDR
The kinetic patterns suggest an ordered Bi Bi mechanism of PG-15-HDH reaction, and the results are discussed with respect to their possible biological significance.