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Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.
The circadian oscillator generates a rhythmic output with a period of about 24 hours. Despite extensive studies in several model systems, the biochemical mode of action has not yet been demonstratedExpand
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Light-dependent sequestration of TIMELESS by CRYPTOCHROME.
Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a proteinExpand
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The Drosophila Circadian Network Is a Seasonal Timer
Previous work in Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning andExpand
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Genome-Wide Expression Analysis in DrosophilaReveals Genes Controlling Circadian Behavior
In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation. Although we haveExpand
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Circadian Remodeling of Neuronal Circuits Involved in Rhythmic Behavior
Clock output pathways are central to convey timing information from the circadian clock to a diversity of physiological systems, ranging from cell-autonomous processes to behavior. While theExpand
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A methyl transferase links the circadian clock to the regulation of alternative splicing
Circadian rhythms allow organisms to time biological processes to the most appropriate phases of the day–night cycle. Post-transcriptional regulation is emerging as an important component ofExpand
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Adult-Specific Electrical Silencing of Pacemaker Neurons Uncouples Molecular Clock from Circadian Outputs
BACKGROUND Circadian rhythms regulate physiology and behavior through transcriptional feedback loops of clock genes running within specific pacemaker cells. In Drosophila, molecular oscillations inExpand
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Cotyledons: an Explant for Routine Regeneration of Sunflower Plants
The potential of plant regeneration from sunflower cotyledon explants was studied under conditions either to allow direct regeneration (organogenesis) or callus proliferation with high regenerationExpand
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Guidelines for Genome-Scale Analysis of Biological Rhythms
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites,Expand
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Impaired clock output by altered connectivity in the circadian network
Substantial progress has been made in elucidating the molecular processes that impart a temporal control to physiology and behavior in most eukaryotes. In Drosophila, dorsal and ventral neuronalExpand
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