M. F. Aillaud | Semantic Scholar

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Plasma thrombin-activatable fibrinolysis inhibitor antigen concentration and genotype in relation to myocardial infarction in the north and south of Europe.

Iréne Juhan-Vague, P. E. Morange, +10 authors Stephen E. Humphries
Arteriosclerosis, thrombosis, and vascular…
2002

The thrombin-activatable fibrinolysis inhibitor (TAFI) is a recently described inhibitor of fibrinolysis that decreases plasminogen binding to the fibrin surface. The plasma TAFI concentration is… (More)

Associations of fibrinogen, factor VII and PAI-1 with baseline findings among 10,500 male participants in a prospective study of myocardial infarction--the PRIME Study. Prospective Epidemiological…

Pierre Y. Scarabin, M. F. Aillaud, +5 authors Iréne Juhan-Vague
Thrombosis and haemostasis
1998

The contribution of coagulation factors and fibrinolytic variables to the development of ischaemic arterial disease is still not clearly established. The PRIME study is a prospective cohort study of… (More)

Clearance of tissue plasminogen activator (TPA) and TPA/plasminogen activator inhibitor type 1 (PAI-1) complex: relationship to elevated TPA antigen in patients with high PAI-1 activity levels.

Wayne L Chandler, Marie Christine Alessi, M. F. Aillaud, P Henderson, Ph. Vague, Iréne Juhan-Vague
Circulation
1997

BACKGROUND To evaluate the effect of plasminogen activator inhibitor type 1 (PAI-1) levels on the clearance of total tissue plasminogen activator (TPA) antigen, we studied the clearance of active TPA… (More)

Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study.

Daniel Kelberman, Emma Hawe, +10 authors Stephen E. Humphries
Thrombosis and haemostasis
2004

Elevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease. We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C)… (More)

Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity.

Sophie Gandrille, Marion Alhenc-Gelas, +4 authors Martine Aiach
Blood
1993

We describe five families presenting with type II hereditary protein C deficiency characterized by normal antigen and amidolytic activity levels but low anticoagulant activity. All the exons and… (More)

Influence of six mutations of the protein C gene on the Gla domain conformation and calcium affinity.

Pascale Gaussem, Sophie Gandrille, +4 authors Martine Aiach
Thrombosis and haemostasis
1994

The protein C Gla domain was studied in six families presenting a type II hereditary deficiency characterized by low activity in a coagulation assay and normal activity in an amidolytic assay. Five… (More)

Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects.

Ph. Vague, Iréne Juhan-Vague, +4 authors Désiré Collen
Metabolism: clinical and experimental
1986

This study was undertaken to obtain further information on the mechanism by which blood fibrinolytic activity, a balance between plasminogen activators and inhibitors, is lowered in obese subjects.… (More)

Antiphospholipids in hemodialysis patients: relationship between lupus anticoagulant and thrombosis.

Philippe Brunet, M. F. Aillaud, +5 authors Yvon Berland
Kidney international
1995

Vascular access thrombosis (VAT) is frequent in some hemodialysis patients. Antiphospholipid antibodies (APL) have been involved in thrombosis, and have been reported to be present in a high… (More)

Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosis.

Iréne Juhan-Vague, J Valadier, +6 authors Désiré Collen
Thrombosis and haemostasis
1987

The fibrinolytic system was investigated in 120 patients with spontaneous or recurrent deep vein thrombosis (DVT) without any known organic disease able to explain by itself the occurrence of a… (More)

Metabolic determinants are much more important than genetic polymorphisms in determining the PAI-1 activity and antigen plasma concentrations: a family study with part of the Stanislas Cohort.

Mireille Henry, David A Trégouët, +5 authors Iréne Juhan-Vague
Arteriosclerosis, thrombosis, and vascular…
1998

Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentration has been identified as a risk factor for coronary heart disease. We investigated the relative contribution of both metabolic… (More)