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Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach
Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.
International consensus on (ICON) pediatric asthma
The purpose of this document is to highlight the key messages that are common to many of the existing guidelines, while critically reviewing and commenting on any differences, thus providing a concise reference.
Recommendations for the assessment and management of cough in children
Current evidence has highlighted that parental reporting of the frequency and severity of a child’s cough is unreliable compared with objective measures, and this is especially true for nocturnal cough.
Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasis
In all three conditions, impaired muco‐ciliary clearance seems to be the common risk factor that provides organisms the opportunity to colonize the lower airway, and the principles of managing PBB, CSLD and bronchiectasis are the same.
Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection.
The results indicate that neutrophils probably play a major part in causing symptoms in these infants and do not support the concept that excessive lymphocyte mediated cytotoxic activity is principally responsible for the pathology in respiratory syncytial virus bronchiolitis.
Getting to grips with 'dysfunctional breathing'.
What the pulmonary specialist should know about the new inhalation therapies
A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was facilitated by the European Respiratory Society (ERS) and the International Society for Aerosols in…
Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a–mediated T reg expansion
- Jason P Lynch, R. Werder, S. Phipps
- Medicine, BiologyThe Journal of experimental medicine
- 5 February 2018
Treatment of pDC-depleted neonates with the microbial-derived metabolite propionate promoted Sema4a-dependent T reg cell expansion, ameliorating both diseases and highlighting a common but age-related Sema 4a-mediated pathway by which pDCs and microbial colonization induce Treg cell expansion to protect against severe bronchiolitis and subsequent asthma.
Flow early in the inspiratory manoeuvre affects the aerosol particle size distribution from a Turbuhaler.
ERS statement on protracted bacterial bronchitis in children
The current knowledge regarding PBB is presented, including the definition, microbiology data, known pathobiology, bronchoalveolar lavage findings and treatment strategies to manage these children, with several major clinical areas in PBB requiring further research.