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Oxidative DNA damage: mechanisms, mutation, and disease

This review critically addresses the extent to which the in vitro significance of oxidative DNA damage has relevance for the pathogenesis of disease, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage.
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SHEAR MODULUS AND DAMPING RELATIONSHIPS FOR GRAVELS

Two of the most important parameters in any dynamic analysis involving soils are the shear modulus and the damping ratio. Because both shear modulus and damping are strain dependent, curves must be…
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Oxidative DNA damage and disease: induction, repair and significance.

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Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing

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Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment

Calcineurin is emphasized as a vital player in the regulation of intrinsic plasticity as governed by the AIS because neither membrane resistance changes nor spine density changes were affected by FK506 treatment, suggesting that calcineur in acts via a separate pathway to modulate AIS plasticity.
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Urinary 8-oxo-2′-deoxyguanosine — Source, significance and supplements

It is suggested that nucleotide excision repair and the action of a specific endonuclease may, in addition to the nucleotide pool, contribute significantly to levels of 8-oxodG in the urine.
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Toward consensus in the analysis of urinary 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine as a noninvasive biomarker of oxidative stress

This study reveals greater consensus than previously expected in the analysis of urinary 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine as a noninvasive biomarker of oxidative stress, although concern remains over ELISA.
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Liquefaction Behavior of Sand-Gravel Composites

To quantify the effect of gravel content on the liquefaction resistance of sand-gravel composites, a series of undrained cyclic triaxial tests was performed on sand-gravel composite specimens with…
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IMPACT DAMAGE TO SOYBEAN SEED AS AFFECTED BY SURFACE HARDNESS AND SEED ORIENTATION

ABSTRACT Soybean seeds at four moistures were impacted using three impact surfaces, four impact velocities, and five seed orientations. A steel impact surface caused the most damage (41% germination,…
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DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine.

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