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Oxidative DNA damage: mechanisms, mutation, and disease
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, onlyExpand
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Oxidative DNA damage and disease: induction, repair and significance.
The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intracellular signalling, and detrimental, modifying cellular biomolecules, accumulationExpand
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SHEAR MODULUS AND DAMPING RELATIONSHIPS FOR GRAVELS
Two of the most important parameters in any dynamic analysis involving soils are the shear modulus and the damping ratio. Because both shear modulus and damping are strain dependent, curves must beExpand
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Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing
Summary Neurons implement a variety of plasticity mechanisms to alter their function over timescales ranging from seconds to days. One powerful means of controlling excitability is to directlyExpand
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Factors contributing to the outcome of oxidative damage to nucleic acids
  • M. Evans, M. Cooke
  • Biology, Medicine
  • BioEssays : news and reviews in molecular…
  • 1 May 2004
Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly elevated levels of such lesions do not always result in cancer remain elusive. Much of the genome isExpand
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Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment
The axon initial segment (AIS) is a specialized neuronal subcompartment located at the beginning of the axon that is crucially involved in both the generation of action potentials and the regulationExpand
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Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor?
Although exposure to exocannabinoids (e.g. marijuana) is associated with adverse pregnancy outcome, little is known about the biochemistry, physiology, and consequences of endocannabinoids in humanExpand
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Urinary 8-oxo-2′-deoxyguanosine — Source, significance and supplements
Oxidative damage to cellular biomolecules, in particular DNA, has been proposed to play an important role in a number of patholgical conditions, including carcinogenesis. A much studied consequenceExpand
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DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine.
The repair of oxidatively damaged DNA is integral to the maintenance of genomic stability, and hence prevention of a wide variety of pathological conditions, such as aging, cancer and cardiovascularExpand
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Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine.
While ELISA is a frequently used means of assessing 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) in biological fluids, differences in baseline urinary 8-oxodG levels, compared to chromatographicExpand
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