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- Publications
- Influence
Oxidative DNA damage: mechanisms, mutation, and disease
- M. Cooke, M. Evans, M. Dizdaroglu, J. Lunec
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 July 2003
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only… Expand
Oxidative DNA damage and disease: induction, repair and significance.
- M. Evans, M. Dizdaroglu, M. Cooke
- Biology, Medicine
- Mutation research
- 1 September 2004
The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intracellular signalling, and detrimental, modifying cellular biomolecules, accumulation… Expand
SHEAR MODULUS AND DAMPING RELATIONSHIPS FOR GRAVELS
- K. Rollins, M. Evans, Nathan B. Diehl, W. Daily
- Materials Science
- 1 May 1998
Two of the most important parameters in any dynamic analysis involving soils are the shear modulus and the damping ratio. Because both shear modulus and damping are strain dependent, curves must be… Expand
Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing
- M. Evans, A. S. Dumitrescu, Dennis L. H. Kruijssen, Samuel E. Taylor, M. Grubb
- Biology, Medicine
- Cell reports
- 29 October 2015
Summary Neurons implement a variety of plasticity mechanisms to alter their function over timescales ranging from seconds to days. One powerful means of controlling excitability is to directly… Expand
Factors contributing to the outcome of oxidative damage to nucleic acids
Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly elevated levels of such lesions do not always result in cancer remain elusive. Much of the genome is… Expand
Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment
- M. Evans, Rosanna P. Sammons, +5 authors M. Grubb
- Biology, Medicine
- The Journal of Neuroscience
- 17 April 2013
The axon initial segment (AIS) is a specialized neuronal subcompartment located at the beginning of the axon that is crucially involved in both the generation of action potentials and the regulation… Expand
Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor?
- O. Habayeb, A. Taylor, +4 authors J. C. Konje
- Medicine
- The Journal of clinical endocrinology and…
- 1 November 2004
Although exposure to exocannabinoids (e.g. marijuana) is associated with adverse pregnancy outcome, little is known about the biochemistry, physiology, and consequences of endocannabinoids in human… Expand
Urinary 8-oxo-2′-deoxyguanosine — Source, significance and supplements
- M. Cooke, M. Evans, K. Herbert, J. Lunec
- Chemistry, Medicine
- Free radical research
- 1 January 2000
Oxidative damage to cellular biomolecules, in particular DNA, has been proposed to play an important role in a number of patholgical conditions, including carcinogenesis. A much studied consequence… Expand
DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine.
- M. Cooke, M. Evans, +5 authors R. Olinski
- Biology, Medicine
- Mutation research
- 1 July 2005
The repair of oxidatively damaged DNA is integral to the maintenance of genomic stability, and hence prevention of a wide variety of pathological conditions, such as aging, cancer and cardiovascular… Expand
Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine.
- M. Cooke, R. Singh, +4 authors M. Evans
- Chemistry, Medicine
- Free radical biology & medicine
- 15 December 2006
While ELISA is a frequently used means of assessing 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) in biological fluids, differences in baseline urinary 8-oxodG levels, compared to chromatographic… Expand