Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)
With increasing numbers of complete RV genome sequences becoming available, a standardized RV strain nomenclature system is needed, and the RCWG proposes that individual RV strains are named as follows: RV group/species of origin/country of identification/common name/year of identification /G- and P-type.
X-ray crystallographic structure of the Norwalk virus capsid.
The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure that has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that hasA classical eight-stranded beta-sandwich motif.
From the Fogarty International Center, National Institutes of Health, Bethesda, MD (R.I.G.); the Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for…
Rotavirus gene structure and function.
Detailed analyses with recently characterized immunologic and gene probes and new animal models can be expected to provide a basic understanding of what regulates the primary interactions of these viruses with the gastrointestinal tract and the subsequent responses of infected hosts.
Replication of human noroviruses in stem cell–derived human enteroids
This work reports the successful cultivation of multiple HuNoV strains in enterocytes in stem cell–derived, nontransformed human intestinal enteroid monolayer cultures, which recapitulates the human intestinal epithelium, permits human host-pathogen studies of previously noncultivatable pathogens, and allows the assessment of methods to prevent and treat Hu noV infections.
Sequence and genomic organization of Norwalk virus.
The morphology, size, polarity, and genomic organization of the Norwalk virus indicate it is a member of the Caliciviridae family.
Taxonomy of the caliciviruses.
The International Committee on Taxonomy of Viruses (ICTV) has recently approved several proposals submitted by the present Caliciviridae Study Group. These proposals include the division of the…
Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein
The availability of large amounts of recombinant Norwalk virus particles will allow the development of rapid, sensitive, and reliable tests for the diagnosis of Norwalkirus infection as well as the implementation of structural studies.
Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments
A Rotavirus Classification Working Group (RCWG) including specialists in molecular virology, infectious diseases, epidemiology, and public health was formed, which can assist in the appropriate delineation of new genotypes, thus avoiding duplications and helping minimize errors.
Age-Dependent Diarrhea Induced by a Rotaviral Nonstructural Glycoprotein
Electrophysiologic data from intestinal mucosa showed that the NSP4 114–135 peptide potentiates chloride secretion by a calcium-dependent signaling pathway, and induced diarrhea in young (6 to 10 days old) CD1 mice.