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Axonal damage in acute multiple sclerosis lesions.
One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the other hand, it is widely accepted that… Expand
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
- J. S. Tzartos, M. Friese, +4 authors L. Fugger
- Biology, Medicine
- The American journal of pathology
Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the secretion of… Expand
Thalamic neurodegeneration in multiple sclerosis
- A. Cifelli, M. Arridge, P. Jezzard, M. Esiri, Jacqueline A Palace, P. Matthews
- Annals of neurology
- 1 November 2002
Multiple sclerosis is still regarded primarily as a disease of the white matter. However, recent evidence suggests that there may be significant involvement of gray matter. Here, we have used… Expand
Neocortical neuronal, synaptic, and glial loss in multiple sclerosis
Background: Recent pathologic investigations have shown that neocortical lesions are frequent in multiple sclerosis (MS). Structural MRI has shown that neocortical atrophy occurs early and can be… Expand
Association of interleukin‐1 gene polymorphisms with Alzheimer's disease
Interleukin‐1 (IL‐1) is markedly overexpressed in Alzheimer's disease. We found the IL‐1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167… Expand
Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke
- D. Anthony, B. Ferguson, M. K. Matyzak, K. Miller, M. Esiri, V. Perry
- Neuropathology and applied neurobiology
- 1 October 1997
D.C. Anthony, B. Ferguson, M.K. Matyzak, K.M. Miller, M.M. Esiri and V.H. Perry (1997) Neuropathology and Applied Neurobiology23, 406–415
Axonal damage: a key predictor of outcome in human CNS diseases.
Axonal damage has recently been recognized to be a key predictor of outcome in a number of diverse human CNS diseases, including head and spinal cord trauma, metabolic encephalopathies, multiple… Expand
Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis
We assessed axonal loss in the normal appearing white matter of the corpus callosum in postmortem brains of patients with multiple sclerosis, using quantitative measures of both axonal density and… Expand
Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis.
- N. Evangelou, D. Konz, M. Esiri, S. Smith, J. Palace, P. Matthews
- Medicine, Biology
- Brain : a journal of neurology
- 1 September 2001
Axonal damage is found in both acute and chronic lesions of multiple sclerosis. Direct axon counting in post-mortem tissue has suggested that smaller axons might have a greater susceptibility to… Expand
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.
- R. C. Pearson, M. Esiri, R. Hiorns, G. Wilcock, T. Powell
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 1 July 1985
The numbers and distribution of the neurofibrillary tangles and neuritic plaques have been determined in several areas of the neocortex in brains affected by various degrees of severity of Alzheimer… Expand