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Axonal damage in acute multiple sclerosis lesions.
One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the other hand, it is widely accepted thatExpand
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Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the secretion ofExpand
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Thalamic neurodegeneration in multiple sclerosis
Multiple sclerosis is still regarded primarily as a disease of the white matter. However, recent evidence suggests that there may be significant involvement of gray matter. Here, we have usedExpand
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Neocortical neuronal, synaptic, and glial loss in multiple sclerosis
Background: Recent pathologic investigations have shown that neocortical lesions are frequent in multiple sclerosis (MS). Structural MRI has shown that neocortical atrophy occurs early and can beExpand
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Association of interleukin‐1 gene polymorphisms with Alzheimer's disease
Interleukin‐1 (IL‐1) is markedly overexpressed in Alzheimer's disease. We found the IL‐1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167Expand
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Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke
D.C. Anthony, B. Ferguson, M.K. Matyzak, K.M. Miller, M.M. Esiri and V.H. Perry (1997) Neuropathology and Applied Neurobiology23, 406–415
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Axonal damage: a key predictor of outcome in human CNS diseases.
Axonal damage has recently been recognized to be a key predictor of outcome in a number of diverse human CNS diseases, including head and spinal cord trauma, metabolic encephalopathies, multipleExpand
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Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis
We assessed axonal loss in the normal appearing white matter of the corpus callosum in postmortem brains of patients with multiple sclerosis, using quantitative measures of both axonal density andExpand
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Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis.
Axonal damage is found in both acute and chronic lesions of multiple sclerosis. Direct axon counting in post-mortem tissue has suggested that smaller axons might have a greater susceptibility toExpand
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Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.
The numbers and distribution of the neurofibrillary tangles and neuritic plaques have been determined in several areas of the neocortex in brains affected by various degrees of severity of AlzheimerExpand
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