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LRRN6A/LERN1 (leucine‐rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex
TLDR
In silico gene content analysis of the 15q24‐q26 region, the confirmation of LRRN6A's expression profile, its predicted protein structure and its similarity to nervous system‐expressed LRR proteins with essential roles in nervous system development and maintenance suggest that LRRn6A is a novel gene of relevance in the molecular and cellular neurobiology of vertebrates. Expand
Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24→q26 and 19p13.3→p12
TLDR
A novel gene on chromosome 15, TM6SF1 is isolated and characterized, which encodes a 370 amino acid product with enhanced expression in spleen, testis and peripheral blood leukocytes and leads to a series of eleven genes in 19p13.3→p12 with close homology to genes in 15q24→ q26. Expand
Involvement of Escherichia coli DNA polymerase II in response to oxidative damage and adaptive mutation
TLDR
A well-established polB strain, a dinA Mu d(Apr lac) fusion (GW1010), exhibited wild-type (Pol II+) sensitivity to killing by peroxide, consistent with the accumulation of second-site suppressor mutations. Expand
Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining.
TLDR
It is concluded that FAC, and perhaps all FA gene products, are likely to play a role in the fidelity of end-joining of specific DSB, which likely accounts for the FA-C phenotype of chromosome instability. Expand
Arrest of S-phase progression is impaired in Fanconi anemia cells.
TLDR
The above data suggest that, in response to damage induced by DNA cross-linking agents, the S-phase checkpoint is inefficient in FA cells, which would lead to accumulation of secondary lesions, such as single- and double-strand breaks and gaps. Expand
HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression
TLDR
HMG20A and HMG20B, two novel human HMG box-containing genes, discovered within the EURO-IMAGE Consortium full-length cDNA sequencing initiative are described and determined the genomic structure and expression pattern. Expand
Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24.
TLDR
The existence of the murine BTBD1 and BTBD2 orthologous genes, as well as the partial rat and bovine homologs are shown, and Conservation of multiple pairs of genes between 15q24 and 19p13 suggests their possible common chromosomal origin. Expand
The fidelity of double strand breaks processing is impaired in complementation groups B and D of fanconi anemia, a genetic instability syndrome
TLDR
The results suggest that FA-D and FA-B gene products are likely to play a role in end-joining fidelity of specific DNA double strand breaks, and blunt-ended breaks were sealed with significantly lower fidelity in FA cells, resulting in a higher deletion frequency and a larger deletion size. Expand
Molecular spectra of HPRT deletion mutations in circulating T-lymphocytes in Fanconi anemia patients.
TLDR
It is proposed that FA genes play a role in the control of the fidelity of rejoining of specific DNA ends, which may explain several basic features of FA, such as chromosomal instability and deletion pronenness. Expand
Identification and characterization of UBXD1, a novel UBX domain-containing gene on human chromosome 19p13, and its mouse ortholog.
TLDR
The characterization of UBXD1 has allowed us to define a new class ofUBX domain-containing proteins conserved during evolution, and showed an enhanced presence in testis. Expand
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