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Ventricular self-defibrillation in mammals: age and drug dependence.
Ventricular fibrillation was electrically induced in cats, rabbits, guinea pigs and rats and in old rats short transient VF (TVF) was followed by spontaneous reversion to normal sinus rhythm. Expand
EFFECT OF EDIBLE COATINGS ON QUALITY OF MANDARINS CV. CLEMENULES
- M. Erez
- Materials Science
Polysaccharide-lipid edible composite coatings can extend fruit shelf-life by providing a barrier to gas and water vapor exchange between the fruit and its environment, reduc- ing respiration rate… Expand
Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites.
The data indicate that mu, kappa, and delta opioid receptors exhibit different selectivity toward bivalent ligands whose spanner lengths differ, and enhanced potency associated with different receptor interactions is consistent with simultaneous occupation of proximal recognition sites. Expand
A new group of defibrillatory drugs in the classification of antiarrhythmic agents.
The introduction of this new group of defibrillatingAntiarrhythmic drugs implies the extension of the common classification of antiarrhythmias and ventricular fibrillation. Expand
Potential probe for isolation of the β-adrenoceptor, chloropractolol
A TECHNIQUE which has proved highly successful in the isolation and identification of pharmacological receptors, is the use of a high affinity, selective label which binds irreversibly to the… Expand
Ventricular defibrillating properties of catecholamine uptake inhibitors.
The results show that the ability of these compounds to transfer SVF to TVF is closely related to their potency to inhibit catecholamine reuptake, which may lead to the development of a new class of antiarrhythmic-defibrillatory drugs. Expand
The cardio-protective features of tricyclic antidepressants.
Selectivity in new -adrenergic blocking agents. (3-Amino-2-hydroxypropoxy)benzamides.
The defibrillating effect of high cardial catecholamine level
A new class of antiarrhythmic-defibrillatory agents.
- O. Levy, M. Erez, D. Varon, E. Keinan
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 19 November 2001
Novel dibenzoazepine and 11-oxo-dibenzodiazepine derivatives are shown to be effective ventricular defibrillating drug candidates and exhibit antifibrillatory activity by elevating the fibrillation threshold potential, suggesting that such drugs could be used to treat VF either by themselves or together with electricaldefibrillators. Expand