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Antiplasmodial quinones from Pentas longiflora and Pentas lanceolata.
The dichloromethane/methanol (1:1) extracts of the roots of Pentas longiflora and Pentas lanceolata showed low micromolar (IC(50) = 0.9-3 µg/mL) IN VITRO antiplasmodial activity againstExpand
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Rapid microwave-assisted solid phase peptide synthesis
A microwave-assisted, rapid solid phase peptide synthesis procedure is presented. It has been applied to the coupling of sterically hindered Fmoc-protected amino acids yielding di- and tripeptides.Expand
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Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves.
Thirteen new metabolites, including the polyoxygenated cyclohexene derivatives cleistodiendiol (1), cleistodienol B (3), cleistenechlorohydrins A (4) and B (5), cleistenediols A-F (6-11),Expand
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Flavonoids from Erythrina schliebenii.
Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2-4), and nineteen known natural products (5-23) were isolated and identified from the root, stem bark, andExpand
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NMReDATA, a standard to report the NMR assignment and parameters of organic compounds
Even though NMR has found countless applications in the field of small molecule characterization, there is no standard file format available for the NMR data relevant to structure characterization ofExpand
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Flemingins G-O, cytotoxic and antioxidant constituents of the leaves of Flemingia grahamiana.
The known flemingins A-C (1-3) and nine new chalcones, named flemingins G-O (4-12), along with deoxyhomoflemingin (13) and emodin (14) were isolated from a leaf extract of Flemingia grahamiana. TheExpand
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Chemistry and folding of photomodulable peptides--stilbene and thioaurone-type candidates for conformational switches.
Optimized synthetic strategies for the preparation of photoswitchable molecular scaffolds based on stilbene or on thioaurone chromophores and their conformationally directing properties, as studiedExpand
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N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis.
Seven N-cinnamoyltetraketides (1-7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of ToussaintiaExpand
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Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins.
Protein-protein interactions that have large, flat and featureless binding sites are difficult drug targets. In the development of their modulators conventional drug discovery strategies are oftenExpand
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Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata
In our search for new antiplasmodial agents, the CH2Cl2/CH3OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitiveExpand
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