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Community acquired pneumonia: aetiology and usefulness of severity criteria on admission.
BACKGROUND: Community acquired pneumonia remains an important cause of hospital admission and carries an appreciable mortality. Criteria for the assessment of severity during admission have been… Expand
Cord-Blood 25-Hydroxyvitamin D Levels and Risk of Respiratory Infection, Wheezing, and Asthma
OBJECTIVE: Higher maternal intake of vitamin D during pregnancy is associated with a lower risk of wheezing in offspring. The relationship between cord-blood levels of 25-hydroxyvitamin D (25[OH]D)… Expand
Lung cancer gene associated with COPD: triple whammy or possible confounding effect?
- R. Young, R. Hopkins, B. Hay, M. Epton, P. Black, G. Gamble
- European Respiratory Journal
- 1 November 2008
Recently, several large genome-wide association studies have identified a putative “lung cancer” locus in the nicotinic acetylcholine receptor subunit genes (nAChR) on 15q25. However, these findings… Expand
Self‐management plans in the primary care of patients with chronic obstructive pulmonary disease
Objective and background: The role of COPD self‐management plans in improving health outcomes remains unclear. The objective of this study was to assess whether self‐management plans administered in… Expand
2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung
BackgroundPseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like"… Expand
Predicting corticosteroid response in chronic obstructive pulmonary disease using exhaled nitric oxide.
- Jack Dummer, M. Epton, +5 authors D. Taylor
- American journal of respiratory and critical care…
- 1 November 2009
RATIONALE Predicting corticosteroid response in COPD is important but difficult. Response is more likely to occur in association with eosinophilic airway inflammation, for which the fraction of… Expand
Breastfeeding protects against current asthma up to 6 years of age.
OBJECTIVE To investigate the effects of breastfeeding on wheezing and current asthma in children 2 to 6 years of age. STUDY DESIGN Infants (n=1105) were enrolled in a prospective birth cohort in… Expand
Chromosome 4q31 locus in COPD is also associated with lung cancer
Chronic obstructive pulmonary disease (COPD) is the single greatest risk factor for lung cancer in smokers and is found in 50–90% of lung cancer cases. The link between COPD and lung cancer may stem… Expand
Elevated concentrations of 1-hydroxypyrene in schoolchildren during winter in Christchurch, New Zealand.
- J. Cavanagh, Leslie Brown, Katherine Trought, S. Kingham, M. Epton
- Environmental Science, Medicine
- The Science of the total environment
- 1 March 2007
Particulate air pollution is significantly elevated during the winter in Christchurch, New Zealand, largely attributable to use of wood burners for domestic home heating, topography, and… Expand
Individual and Cumulative Effects of GWAS Susceptibility Loci in Lung Cancer: Associations after Sub-Phenotyping for COPD
Epidemiological studies show that approximately 20–30% of chronic smokers develop chronic obstructive pulmonary disease (COPD) while 10–15% develop lung cancer. COPD pre-exists lung cancer in 50–90%… Expand