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Bacterial biosensors for monitoring toxic metals.
TLDR
A number of biosensors based on bacteria have recently been developed for monitoring toxic metals in the environment and the advantages and disadvantages of these types of biosensing are discussed. Expand
Aequorin variants with improved bioluminescence properties.
TLDR
Forty-two aequorin mutants were prepared and combined with 10 different coelenterazine analogues in a search for proteins with different emission wavelengths, altered decay kinetics and improved stability, resulting in semi-synthetic photoprotein mutants with significantly altered bioluminescent properties. Expand
Bioluminescence and its impact on bioanalysis.
TLDR
Bioluminescent proteins have found a plethora of analytical applications in intracellular monitoring, genetic regulation and detection, immuno- and binding assays, and whole-cell biosensors, among others. Expand
Does the Stanford Health Assessment Questionnaire have potential as a monitoring tool for subjects with rheumatoid arthritis?
TLDR
Although the value of HAQ as a group outcome measure is well established, this study questions the usefulness of monitoring individual HAQ scores in a clinical setting. Expand
A fluorescence-based sensing system for the environmental monitoring of nickel using the nickel binding protein from Escherichia coli
TLDR
The results suggest that fluorescently labeled NBP is potentially useful in the development of a sensing system for nickel. Expand
Effects of Three Low-Doses of D-Tagatose on Glycemic Control Over Six Months in Subjects with Mild Type 2 Diabetes Mellitus Under Control with Diet and Exercise.
TLDR
Evaluation of the safety and the effect of D-tagatose on the glycemic control of subjects with type 2 diabetes as determined by HbA1c levels at the end of 6 months of therapy using the subject's own baseline Hb a1c level as a comparator found it to be well tolerated. Expand
The long-term use of D-penicillamine for treating rheumatoid arthritis: is continuous therapy necessary?
TLDR
The results suggest that many patients may not comply with their prescribed D-penicillamine regime, but such variation in compliance may not be clinically important since intermittent treatment may sustain response in the longer term. Expand
Aequorin-based homogeneous cortisol immunoassay for analysis of saliva samples.
TLDR
It was demonstrated that the assay can be reliably used to measure the concentration of free cortisol in saliva without significant pretreatment of the sample, thereby making this assay attractive for the analysis of this hormone in biological samples. Expand
Aequorin mutants with increased thermostability
TLDR
The quadruple aequorin mutant, S32T/E156V/Q168R/L170I, exhibited more thermostability at a variety of temperatures than either double mutant alone, producing the most thermostable aequOrin mutant identified thus far. Expand
Safety and Efficacy of D-Tagatose in Glycemic Control in Subjects with Type 2 Diabetes.
TLDR
D-tagatose is an effective single agent at treating many of the therapy targets of type 2 diabetes including lowering fasting blood glucose and HbA1c, and lowering of LDL and total cholesterol in the ITT population. Expand
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