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Lupinacidin C, an inhibitor of tumor cell invasion from Micromonospora lupini.
Lupinacidin C exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.
Novel Photoinduced Squalene Cyclic Peroxide Identified, Detected, and Quantified in Human Skin Surface Lipids
This study shows for the first time the identification and presence of a novel SQ cyclic peroxide “2-OOH-3-(1,2-dioxane)-SQ” in SSLs, shedding light on the importance of further studying its effect and role on the skin.
Structure-activity relationship of optically active 2-(3-pyridyl)thiazolidin-4-ones as a PAF antagonists
Total synthesis of the tremorgenic indole diterpene paspalinine.
A novel total synthesis of paspalinine (1) together with a formal synthesis ofpaspalicine (2) is described that features not only a concise stereoselective formation of the CDE ring system but also a high-yielding convenient installation of the indole moiety and an efficient introduction of the C13 tertiary hydroxy group through allylic selenoxide rearrangement.
Total synthesis of bacilosarcins A and B.
In the course of screening for plant growth regulators ofmicrobial origin, Igarashi and co-workers discovered twonovel herbicidal substances, bacilosarcins A and B, in theculture broth of the…
Stereoselective total synthesis of amicoumacin C
Enantioselective synthesis of the tricyclic core of (+)-strigol
Stereoselective synthesis of the C17–C29 fragment of amphidinolide N
Synthesis of (±)-terpendole E
- T. Teranishi, T. Murokawa, M. Enomoto, S. Kuwahara
- ChemistryBioscience, biotechnology, and biochemistry
- 2 January 2015
The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves…