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The regulatory role of natural killer cells in multiple sclerosis.
TLDR
It is reported that in the majority of multiple sclerosis patients in a state of remission, natural killer cells contain unusually high frequencies of the cells expressing CD95 (Fas) on their surface, and NK cells may actively suppress potentially pathogenic autoimmune T cells that can mediate the inflammatory responses in the CNS. Expand
DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice.
TLDR
This DM-20-induced EAE in mice may provide a valuable model because it is similar to multiple sclerosis and because it can be induced in inbred mice in which immune mechanisms can be easily studied. Expand
No effect of anti-leprosy drugs in the prevention of Alzheimer’s disease and β-amyloid neurotoxicity
TLDR
The present study suggests that anti-leprosy treatments do not prevent the onset of AD and it is now important to examine the infection of Mycobacterium leprae in the central nervous system to clarify the reason for the low prevalence of senile dementia, and low frequency of Abeta deposition in leprosy patients. Expand
Leprosy in hypertensive nude rats (SHR/NCrj-rnu).
TLDR
It is reconfirmed that hypertensive SHR/NCrj-rnu rats of the NE12F3 generation were highly susceptible to M. leprae. Expand
Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein
TLDR
It is suggested that PLP is encephalitogenic and produces demyelination in the central nervous system without contamination by MBP or GC in Hartley guinea pigs. Expand
Ia expression in chronic relapsing experimental allergic encephalomyelitis induced by long-term cultured T cell lines in mice.
TLDR
The data indicate that MBP-reactive T cells persist at least in the spleen, for a long time, and may be reactivated by certain mechanisms probably in the central nervous system associated with the Ia-antigen expression, which facilitates the effector phase again. Expand
Humoral immune responses to myelin basic protein, cerebroside and ganglioside in chronic relapsing experimental allergic encephalomyelitis of the guinea pig
Titers of serum antibodies to myelin basic protein, cerebroside and ganglioside were determined in chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs at variousExpand
Thioredoxin from activated macrophages as a trophic factor for central cholinergic neurons in vitro.
TLDR
The conditioned medium from gamma-interferon-stimulated macrophages elevated the choline acetyltransferase activity in mouse septal neurons as well as in cholinergic hybrid cell lines SN6.10.2.2 in vitro and the neurotrophic activity of recombinant TRX was confirmed. Expand
Antibodies to proteolipid apoprotein in chronic relapsing experimental allergic encephalomyelitis
TLDR
Titers of serum antibodies to proteolipid apoprotein (PLP) were determined in chronic relapsing experimental allergic encephalomyelitis of strain 13 guinea pigs sensitized with whole central nervous system tissue, and the high titers of anti-PLP antibodies seem to have something to do with the immunologic mechanisms of chronic relapsesing EAE. Expand
Causes of Thrombocytopenia in Chronic Hepatitis C Viral Infection
TLDR
The present results imply that vascular endothelial dysfunction is also involved in thrombocytopenia during chronic HCV infection. Expand
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