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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
Lentiviral delivery of glial cell line-derived neurotrophic factor (lenti-GDNF) was tested for its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of Parkinson'sExpand
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Lentivirally Delivered Glial Cell Line-Derived Neurotrophic Factor Increases the Number of Striatal Dopaminergic Neurons in Primate Models of Nigrostriatal Degeneration
The primate striatum contains tyrosine hydroxylase (TH)-immunoreactive (ir) neurons, the numbers of which are augmented after dopamine depletion. Glial cell line-derived neurotrophic factor (GDNF)Expand
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Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells
By sequentially applying sonic hedgehog (C25II) and CHIR99021 (GSK3β inhibitor) to induce the midbrain floor plate (FP) progenitors and fibroblast growth factor 8 (FGF8) to promote dopaminergicExpand
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Age‐related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys
Although the role of dopamine dysfunction is well established in Parkinson's disease, the effect of nigrostriatal degeneration on motor performance during normal aging is less well understood. InExpand
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Evaluation of animal models of Parkinson's disease for neuroprotective strategies
  • M. Emborg
  • Psychology, Medicine
  • Journal of Neuroscience Methods
  • 30 October 2004
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic nigral neurons and striatal dopamine. Despite the advances of modern therapy toExpand
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Contributions of non-human primates to neuroscience research
Non-human primates have a small but important role in basic and translational biomedical research, owing to similarities with human beings in physiology, cognitive capabilities, neuroanatomy, socialExpand
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Chronic ischemic stroke model in cynomolgus monkeys: Behavioral, neuroimaging and anatomical study
Abstract Previous nonhuman primate stroke models have employed temporary occlusion of arteries, had limited behavioral testing and imaging, and focused on the short-term outcome. Our goals were 1. toExpand
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Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system
A mouse monoclonal antibody (clone 62‐2E8) raised against a human recombinant high‐affinity choline transporter (CHT)‐glutathione‐S‐transferase fusion protein was used to determine the distributionExpand
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Subthalamic Glutamic Acid Decarboxylase Gene Therapy: Changes in Motor Function and Cortical Metabolism
Parkinson's disease (PD) is associated with increased excitatory activity within the subthalamic nucleus (STN). We sought to inhibit STN output in hemiparkinsonian macaques by transfection withExpand
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Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain.
The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neuralExpand
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