M. Elphick

Publications155
h-index38
Citations8,149
Highly Influential Citations501
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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9-tetrahydrocannabinol, numerous… Expand
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The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus
Balanced control of neuronal activity is central in maintaining function and viability of neuronal circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show that… Expand
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MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
  • L. Chan, T. Webb, +9 authors A. Clark
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 14 April 2009
The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R–MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic–pituitary–adrenal axis,… Expand
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The Genome of the Sea Urchin Strongylocentrotus purpuratus
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined… Expand
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Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C‐terminal tail of CB1
The CB1‐type cannabinoid receptor mediates physiologic effects of Δ9‐tetrahydrocannabinol, the psychoactive ingredient of the drug marijuana. In this report, the authors analyse the expression of CB1… Expand
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The neurobiology and evolution of cannabinoid signalling.
The plant Cannabis sativa has been used by humans for thousands of years because of its psychoactivity. The major psychoactive ingredient of cannabis is Delta(9)-tetrahydrocannabinol, which exerts… Expand
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Comparative analysis of fatty acid amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of…
Fatty acid amide hydrolase (FAAH) catalyses hydrolysis of the endocannabinoid arachidonoylethanolamide ("anandamide") in vitro and regulates anandamide levels in the brain. In the cerebellar cortex,… Expand
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Cannabinoid CB1 Receptor Expression in Rat Spinal Cord
While evidence implicates the endogenous cannabinoid system as a novel analgesic target at a spinal level, detailed analysis of the distribution of the cannabinoid receptor CB1 in spinal cord has not… Expand
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A genomic view of the sea urchin nervous system.
The sequencing of the Strongylocentrotus purpuratus genome provides a unique opportunity to investigate the function and evolution of neural genes. The neurobiology of sea urchins is of particular… Expand
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A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.
CB1–type cannabinoid receptors in the brain mediate effects of the drug cannabis. Anandamide and sn–2 arachidonylglycerol (2–AG) are putative endogenous ligands for CB1 receptors, but it is not known… Expand
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