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A synthetic oscillatory network of transcriptional regulators
Networks of interacting biomolecules carry out many essential functions in living cells, but the ‘design principles’ underlying the functioning of such intracellular networks remain poorlyExpand
Stochastic Gene Expression in a Single Cell
Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can be essential for many biological processes and is conjectured to arise from stochasticity, or noise, inExpand
Dynamics of the p53-Mdm2 feedback loop in individual cells
The tumor suppressor p53, one of the most intensely investigated proteins, is usually studied by experiments that are averaged over cell populations, potentially masking the dynamic behavior inExpand
Intrinsic and extrinsic contributions to stochasticity in gene expression
Gene expression is a stochastic, or “noisy,” process. This noise comes about in two ways. The inherent stochasticity of biochemical processes such as transcription and translation generatesExpand
Gene Regulation at the Single-Cell Level
The quantitative relation between transcription factor concentrations and the rate of protein production from downstream genes is central to the function of genetic networks. Here we show that thisExpand
Protein mobility in the cytoplasm of Escherichia coli.
The rate of protein diffusion in bacterial cytoplasm may constrain a variety of cellular functions and limit the rates of many biochemical reactions in vivo. In this paper, we report noninvasiveExpand
An excitable gene regulatory circuit induces transient cellular differentiation
Certain types of cellular differentiation are probabilistic and transient. In such systems individual cells can switch to an alternative state and, after some time, switch back again. In BacillusExpand
Functional roles for noise in genetic circuits
The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or ‘noise’, in the levels of their components. Noise, far from just a nuisance, has begun to beExpand
Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing.
Diverse biochemical rhythms are generated by thousands of cellular oscillators that somehow manage to operate synchronously. In fields ranging from circadian biology to endocrinology, it remains anExpand
Frequency-modulated nuclear localization bursts coordinate gene regulation
In yeast, the transcription factor Crz1 is dephosphorylated and translocates into the nucleus in response to extracellular calcium. Here we show, using time-lapse microscopy, that Crz1 exhibits shortExpand
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