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Sex and strain dependent differences in mucosal immunology and microbiota composition in mice
BackgroundA dysbiosis in the intestinal microbiome plays a role in the pathogenesis of several immunological diseases. These diseases often show a sex bias, suggesting sex differences in immuneExpand
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β2→1-Fructans Modulate the Immune System In Vivo in a Microbiota-Dependent and -Independent Fashion
It has been shown in vitro that only specific dietary fibers contribute to immunity, but studies in vivo are not conclusive. Here, we investigated degree of polymerization (DP) dependent effects ofExpand
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The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice
A mucus layer covers and protects the intestinal epithelial cells from direct contact with microbes. This mucus layer not only prevents inflammation but also plays an essential role in microbiotaExpand
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Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity
Aging significantly increases the vulnerability to gastrointestinal (GI) disorders but there are few studies investigating the key factors in aging that affect the GI tract. To address this knowledgeExpand
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Modulation of Intestinal Epithelial Glycocalyx Development by Human Milk Oligosaccharides and Non‐Digestible Carbohydrates
Scope The epithelial glycocalyx development is of great importance for microbial colonization. Human milk oligosaccharides (hMOs) and non‐digestible carbohydrates (NDCs) may modulate glycocalyxExpand
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Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B.
SCOPE In vivo studies demonstrating that only specific dietary-fibers contribute to immunity are still inconclusive, as measuring immune effects in healthy humans remains difficult. We applied aExpand
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Role of Microbiota in Sexually Dimorphic Immunity
Sex differences in peripheral immune responses are well recognized. This is associated with sex differences in many immunological diseases. As the intestinal microbiota is known to influence theExpand
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Sex impacts Th1 cells, Tregs, and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner
BackgroundMales and females have a different predisposition for the development of intestinal disorders, like inflammatory bowel disease (IBD). We hypothesized that sex specific differences inExpand
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Changes in intestinal gene expression and microbiota composition during late pregnancy are mouse strain dependent
Hormones and placental factors are thought to underlie the maternal immunological changes during pregnancy. However, as several intestinal microbiota are linked to immune modulations, we hypothesizedExpand
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