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- Publications
- Influence
Sex and strain dependent differences in mucosal immunology and microbiota composition in mice
- M. Elderman, Floor Hugenholtz, +6 authors M. Faas
- Biology, Medicine
- Biology of Sex Differences
- 18 June 2018
BackgroundA dysbiosis in the intestinal microbiome plays a role in the pathogenesis of several immunological diseases. These diseases often show a sex bias, suggesting sex differences in immune… Expand
β2→1-Fructans Modulate the Immune System In Vivo in a Microbiota-Dependent and -Independent Fashion
- Floris Fransen, N. Sahasrabudhe, +12 authors P. de Vos
- Biology, Medicine
- Front. Immunol.
- 16 February 2017
It has been shown in vitro that only specific dietary fibers contribute to immunity, but studies in vivo are not conclusive. Here, we investigated degree of polymerization (DP) dependent effects of… Expand
The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice
- M. Elderman, B. Sovran, +9 authors M. Faas
- Biology, Medicine
- PloS one
- 12 September 2017
A mucus layer covers and protects the intestinal epithelial cells from direct contact with microbes. This mucus layer not only prevents inflammation but also plays an essential role in microbiota… Expand
Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity
- B. Sovran, Floor Hugenholtz, +8 authors J. Wells
- Biology, Medicine
- Scientific Reports
- 5 February 2019
Aging significantly increases the vulnerability to gastrointestinal (GI) disorders but there are few studies investigating the key factors in aging that affect the GI tract. To address this knowledge… Expand
Modulation of Intestinal Epithelial Glycocalyx Development by Human Milk Oligosaccharides and Non‐Digestible Carbohydrates
- Chunli Kong, M. Elderman, Lianghui Cheng, B. D. de Haan, A. Nauta, P. de Vos
- Chemistry, Medicine
- Molecular nutrition & food research
- 11 June 2019
Scope The epithelial glycocalyx development is of great importance for microbial colonization. Human milk oligosaccharides (hMOs) and non‐digestible carbohydrates (NDCs) may modulate glycocalyx… Expand
Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B.
- Leonie M Vogt, M. Elderman, T. Borghuis, B. D. de Haan, M. Faas, P. de Vos
- Biology, Medicine
- Molecular nutrition & food research
- 1 October 2017
SCOPE
In vivo studies demonstrating that only specific dietary-fibers contribute to immunity are still inconclusive, as measuring immune effects in healthy humans remains difficult. We applied a… Expand
Role of Microbiota in Sexually Dimorphic Immunity
- M. Elderman, P. de Vos, M. Faas
- Biology, Medicine
- Front. Immunol.
- 22 May 2018
Sex differences in peripheral immune responses are well recognized. This is associated with sex differences in many immunological diseases. As the intestinal microbiota is known to influence the… Expand
Sex impacts Th1 cells, Tregs, and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner
- M. Elderman, A. V. van Beek, +4 authors M. Faas
- Medicine, Biology
- Biology of Sex Differences
- 5 April 2016
BackgroundMales and females have a different predisposition for the development of intestinal disorders, like inflammatory bowel disease (IBD). We hypothesized that sex specific differences in… Expand
Changes in intestinal gene expression and microbiota composition during late pregnancy are mouse strain dependent
- M. Elderman, Floor Hugenholtz, +4 authors M. Faas
- Biology, Medicine
- Scientific Reports
- 3 July 2018
Hormones and placental factors are thought to underlie the maternal immunological changes during pregnancy. However, as several intestinal microbiota are linked to immune modulations, we hypothesized… Expand