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Accelerometry of Adductor Pollicis Muscle Predicts Recovery of Respiratory Function from Neuromuscular Blockade
Background Residual paralysis increases the risk of pulmonary complications but is difficult to detect. To test the hypothesis that accelerometry predicts effects of residual paralysis on pulmonary… Expand
Diaphragm muscle thinning in patients who are mechanically ventilated.
BACKGROUND Approximately 40% of patients in medical ICUs require mechanical ventilation (MV). Approximately 20% to 25% of these patients will encounter difficulties in discontinuing MV. Multiple… Expand
Reversal of Profound, High-dose Rocuronium–induced Neuromuscular Blockade by Sugammadex at Two Different Time Points: An International, Multicenter, Randomized, Dose-finding, Safety Assessor–blinded,…
Background:Sugammadex (Org 25969), a novel, selective relaxant binding agent, was specifically designed to rapidly reverse rocuronium-induced neuromuscular blockade. The efficacy and safety of… Expand
Intraoperative protective mechanical ventilation and risk of postoperative respiratory complications: hospital based registry study
- K. Ladha, M. V. Vidal Melo, +4 authors M. Eikermann
- BMJ : British Medical Journal
- 14 July 2015
Objective To evaluate the effects of intraoperative protective ventilation on major postoperative respiratory complications and to define safe intraoperative mechanical ventilator settings that do… Expand
The influence of aging on pharyngeal collapsibility during sleep.
BACKGROUND Aging increases vulnerability to obstructive sleep apnea (OSA), but the underlying mechanisms remain unclear. Recent data in awake healthy volunteers show a decrease in the genioglossus… Expand
Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea
The purpose of the Society of Anesthesia and Sleep Medicine guideline on preoperative screening and assessment of adult patients with obstructive sleep apnea (OSA) is to present recommendations based… Expand
The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade.
- M. Eikermann, F. Vogt, +5 authors J. Peters
- American journal of respiratory and critical care…
RATIONALE Partial neuromuscular transmission failure by acetylcholine receptor blockade (neuromuscular blockade) or antibody-mediated functional loss (myasthenia gravis), even with a magnitude of… Expand
Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications
- D. McLean, D. Diaz-Gil, Hassan N Farhan, K. Ladha, T. Kurth, M. Eikermann
- 1 June 2015
Background:Duration of action increases with repeated administration of neuromuscular-blocking agents, and intraoperative use of high doses of neuromuscular-blocking agent may affect respiratory… Expand
Effects of sugammadex on incidence of postoperative residual neuromuscular blockade: a randomized, controlled study.
- B. Brueckmann, N. Sasaki, +11 authors M. Eikermann
- British journal of anaesthesia
- 1 November 2015
BACKGROUND This study aimed to investigate whether reversal of rocuronium-induced neuromuscular blockade with sugammadex reduced the incidence of residual blockade and facilitated operating room… Expand
Postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge.
- A. Butterly, E. Bittner, E. George, W. Sandberg, M. Eikermann, U. Schmidt
- British journal of anaesthesia
- 1 September 2010
BACKGROUND Postoperative residual curarization (PORC) [train-of-four ratio (T4/T1) <0.9] is associated with increased morbidity and may delay postoperative recovery room (PACU) discharge. We tested… Expand